Protein kinases in control of the centrosome cycle - PubMed (original) (raw)

Review

. 1999 Jun 4;452(1-2):92-5.

doi: 10.1016/s0014-5793(99)00534-7.

Affiliations

Free article

Review

Protein kinases in control of the centrosome cycle

T Mayor et al. FEBS Lett. 1999.

Free article

Abstract

The centrosome is the major microtubule nucleating center of the animal cell and forms the two poles of the mitotic spindle upon which chromosomes are segregated. During the cell division cycle, the centrosome undergoes a series of major structural and functional transitions that are essential for both interphase centrosome function and mitotic spindle formation. The localization of an increasing number of protein kinases to the centrosome has revealed the importance of protein phosphorylation in controlling many of these transitions. Here, we focus on two protein kinases, the polo-like kinase 1 and the NIMA-related kinase 2, for which recent data indicate key roles during the centrosome cycle.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources