Entry sites for oral vaccines and drugs: A role for M cells, enterocytes and dendritic cells? - PubMed (original) (raw)

Review

Entry sites for oral vaccines and drugs: A role for M cells, enterocytes and dendritic cells?

D Kaiserlian et al. Semin Immunol. 1999 Jun.

Abstract

M cells have long been considered as the unique entry site of macromolecules and pathogens in the intestine, allowing delivery to antigen-presenting cells in the Peyer's patches. Therefore, antigen formulation for the development of oral vaccines has been based on administration of antigens in the form of live replicating pathogens or soluble antigen vectorized into biodegradable microspheres. However, progress in the understanding of the biology of dendritic cells, as well as identification of their localization at different sites of the intestine, suggest that they may capture antigen directly from the lumen of mucosal tissues or from epithelial cells of the intestine. Besides, a role for the absorptive epithelium in antigen presentation through both classical or non-classical MHC elements suggests that PP may not be the exclusive inductive site of the immune response in the gut. Thus, depending on the nature of the antigen (soluble or infectious) there may be different sites of antigen entry through the intestine, and each site may have distinct efficiency to promote a protective immune response, depending on the presence and function of dendritic cells. Cross talk between M cells, epithelial cells and dendritic cells may play an important role in determining the outcome of tolerance versus immunity.

Copyright 1999 Academic Press.

PubMed Disclaimer

Similar articles

• Involvement of dendritic cell subsets in the induction of oral tolerance and immunity.
  Fleeton M, Contractor N, Leon F, He J, Wetzel D, Dermody T, Iwasaki A, Kelsall B. Fleeton M, et al. Ann N Y Acad Sci. 2004 Dec;1029:60-5. doi: 10.1196/annals.1309.008. Ann N Y Acad Sci. 2004. PMID: 15681744
• New generation of mucosal adjuvants for the induction of protective immunity.
  Yuki Y, Kiyono H. Yuki Y, et al. Rev Med Virol. 2003 Sep-Oct;13(5):293-310. doi: 10.1002/rmv.398. Rev Med Virol. 2003. PMID: 12931340 Review.
• Phenotype and function of intestinal dendritic cells.
  Johansson C, Kelsall BL. Johansson C, et al. Semin Immunol. 2005 Aug;17(4):284-94. doi: 10.1016/j.smim.2005.05.010. Semin Immunol. 2005. PMID: 15978836 Review.
• M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis.
  Corr SC, Gahan CC, Hill C. Corr SC, et al. FEMS Immunol Med Microbiol. 2008 Jan;52(1):2-12. doi: 10.1111/j.1574-695X.2007.00359.x. Epub 2007 Dec 10. FEMS Immunol Med Microbiol. 2008. PMID: 18081850 Review.
• Exploiting receptor biology for oral vaccination with biodegradable particulates.
  Foster N, Hirst BH. Foster N, et al. Adv Drug Deliv Rev. 2005 Jan 10;57(3):431-50. doi: 10.1016/j.addr.2004.09.009. Adv Drug Deliv Rev. 2005. PMID: 15560950 Review.

Cited by

• Virus recognition by specific natural antibodies and complement results in MHC I cross-presentation.
  Dürrbach A, Baple E, Preece AF, Charpentier B, Gustafsson K. Dürrbach A, et al. Eur J Immunol. 2007 May;37(5):1254-65. doi: 10.1002/eji.200636129. Eur J Immunol. 2007. PMID: 17407191 Free PMC article.
• Intranasal vaccination against cutaneous leishmaniasis with a particulated leishmanial antigen or DNA encoding LACK.
  Pinto EF, Pinheiro RO, Rayol A, Larraga V, Rossi-Bergmann B. Pinto EF, et al. Infect Immun. 2004 Aug;72(8):4521-7. doi: 10.1128/IAI.72.8.4521-4527.2004. Infect Immun. 2004. PMID: 15271911 Free PMC article.
• Yersinia enterocolitica as a vehicle for a naked DNA vaccine encoding Brucella abortus bacterioferritin or P39 antigen.
  Al-Mariri A, Tibor A, Lestrate P, Mertens P, De Bolle X, Letesson JJ. Al-Mariri A, et al. Infect Immun. 2002 Apr;70(4):1915-23. doi: 10.1128/IAI.70.4.1915-1923.2002. Infect Immun. 2002. PMID: 11895955 Free PMC article.
• Targeting vaccines to dendritic cells.
  Foged C, Sundblad A, Hovgaard L. Foged C, et al. Pharm Res. 2002 Mar;19(3):229-38. doi: 10.1023/a:1014474414097. Pharm Res. 2002. PMID: 11934227 Review.
• Antigen transport into Peyer's patches: increased uptake by constant numbers of M cells.
  Gebert A, Steinmetz I, Fassbender S, Wendlandt KH. Gebert A, et al. Am J Pathol. 2004 Jan;164(1):65-72. doi: 10.1016/S0002-9440(10)63097-0. Am J Pathol. 2004. PMID: 14695320 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal