Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development - PubMed (original) (raw)
Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development
G Eberl et al. Eur J Immunol. 1999 Jun.
Free article
Abstract
Most natural killer T (NKT) cells express a highly skewed alphabeta TCR repertoire, consisting of an invariant V alpha14-J alpha281 chain paired preferentially with a polyclonal Vbeta8.2 chain. This repertoire is positively selected by the monomorphic CD1d molecule expressed on cells of hematopoietic origin. The origin of NKT cells and their lineage relationship to conventional T cells is controversial. We show here that the development of NKT cells is absolutely dependent on expression of the pre-TCRalpha chain, in marked contrast to conventional T cells which arise in significant numbers even in the absence of a functional pre-TCR. Distinct developmental requirements for pre-TCR expression in the NKT and T cell lineages may reflect differences in the ability of the TCRalphabeta to substitute functionally for the pre-TCR in immature precursor cells.
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