Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits - PubMed (original) (raw)

Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits

D Choi et al. Korean J Parasitol. 1999 Jun.

Abstract

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.

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Figures

Fig. 1

Fig. 1

Sonograms of a rabbit (ID, 500-1) 9 weeks after infection with 500 metacercariae of Clonorchis sinensis. A. Transverse scan of the left hepatic lobe shows severe dilatation of the intrahepatic ducts (arrows). Note the hyperechoic bands along the duct wall, representing periductal fibrosis. B. Oblique scan of the gallbladder shows a few small echogenic foci (arrow) possibly indicating worms or desquamated materials.

Fig. 2

Fig. 2

A rabbit (ID, 500-5) 18 months after treatment. A. Sonogram still shows moderate dilatation of the peripheral intrahepatic ducts with increased periductal echogenicity (arrows). B. Photomicrograph shows moderately persisted dilatation of the intrahepatic ducts and mucosal hyperplasia (arrows). Also note remaining periductal fibrosis which has been least resolved.

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