Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein - PubMed (original) (raw)
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
D R Taylor et al. Science. 1999.
Abstract
Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2alpha, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.
Comment in
- The scientific challenge of hepatitis C.
Cohen J. Cohen J. Science. 1999 Jul 2;285(5424):26-30. doi: 10.1126/science.285.5424.26. Science. 1999. PMID: 10428695 No abstract available. - Hepatitis C virus, the E2 envelope protein, and alpha-interferon resistance.
Abid K, Quadri R, Negro F. Abid K, et al. Science. 2000 Mar 3;287(5458):1555. doi: 10.1126/science.287.5458.1555a. Science. 2000. PMID: 10733410 No abstract available.
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