Proton therapy for tumors of the skull base - PubMed (original) (raw)

Review

. 1999 Jun:175 Suppl 2:57-63.

doi: 10.1007/BF03038890.

Affiliations

• PMID: 10394399
• DOI: 10.1007/BF03038890

Review

Proton therapy for tumors of the skull base

J E Munzenrider et al. Strahlenther Onkol. 1999 Jun.

Abstract

Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can be focused in the target, while achieving significant sparing of the brain, brain stem, cervical cord, and optic nerves and chiasm. For skull base tumors, 10-year local control rates with combined proton-photon therapy are highest for chondrosarcomas, intermediate for male chordomas, and lowest for female chordomas (94%, 65%, and 42%, respectively). For cervical spine tumors, 10-year local control rates are not significantly different for chordomas and chondrosarcomas (54% and 48%, respectively), nor is there any difference in local control between males and females. Observed treatment-related morbidity has been judged acceptable, in view of the major morbidity and mortality which accompany uncontrolled tumor growth.

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