Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells - PubMed (original) (raw)
Comparative Study
. 1999 Jul 15;94(2):701-12.
Affiliations
- PMID: 10397737
Free article
Comparative Study
Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells
G Jego et al. Blood. 1999.
Free article
Abstract
Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19(+) CD38(+) CD138(+) CD40(+) CD45(+) CD11a+ CD49e- CD56(-)). In most cases, a minor subpopulation of CD28(+) plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138(+) plasma cell removal, highly proliferative CD138(-) plasmablasts differentiated into CD138(+) plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and was concomitant with extensive secretion of interleukin-6 (IL-6). The addition of neutralizing anti-IL-6 and anti-CD126 (IL-6 receptor) monoclonal antibodies totally prevented Ig secretion and cell differentiation by inducing apoptosis of plasmablasts, which indicates that IL-6 is an essential survival factor for plasmablasts. This report provides the first characterization of normal plasmablasts and shows that their phenotype is not exactly that of multiple myeloma cells.
Similar articles
- Characterization of a novel interleukin-6 autocrine-dependent human plasma cell line.
Ozaki S, Wolfenbarger D, deBram-Hart M, Kanangat S, Weiss DT, Solomon A. Ozaki S, et al. Leukemia. 1994 Dec;8(12):2207-13. Leukemia. 1994. PMID: 7528862 - Interleukin-6 is a growth factor for nonmalignant human plasmablasts.
Jego G, Bataille R, Pellat-Deceunynck C. Jego G, et al. Blood. 2001 Mar 15;97(6):1817-22. doi: 10.1182/blood.v97.6.1817. Blood. 2001. PMID: 11238125 - CD19-CD45 low/- CD38 high/CD138+ plasma cells enrich for human tumorigenic myeloma cells.
Kim D, Park CY, Medeiros BC, Weissman IL. Kim D, et al. Leukemia. 2012 Dec;26(12):2530-7. doi: 10.1038/leu.2012.140. Epub 2012 May 30. Leukemia. 2012. PMID: 22733078 - The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy.
Bataille R, Jégo G, Robillard N, Barillé-Nion S, Harousseau JL, Moreau P, Amiot M, Pellat-Deceunynck C. Bataille R, et al. Haematologica. 2006 Sep;91(9):1234-40. Haematologica. 2006. PMID: 16956823 Review. - Reactive plasmacytoses, a model for studying the biology of human plasma cell progenitors and precursors.
Pellat-Deceunynck C, Jego G, Robillard N, Accard F, Amiot M, Bataille R. Pellat-Deceunynck C, et al. Hematol J. 2000;1(6):362-6. doi: 10.1038/sj.thj.6200053. Hematol J. 2000. PMID: 11920215 Review. No abstract available.
Cited by
- Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture.
Nguyen DC, Saney C, Hentenaar IT, Cabrera-Mora M, Capric V, Woodruff MC, Andrews J, Lonial S, Sanz I, Lee FE. Nguyen DC, et al. Sci Rep. 2024 Feb 13;14(1):3616. doi: 10.1038/s41598-024-53977-2. Sci Rep. 2024. PMID: 38350990 Free PMC article. - Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19.
Schultheiß C, Paschold L, Willscher E, Simnica D, Wöstemeier A, Muscate F, Wass M, Eisenmann S, Dutzmann J, Keyßer G, Gagliani N, Binder M. Schultheiß C, et al. iScience. 2021 Nov 19;24(11):103325. doi: 10.1016/j.isci.2021.103325. Epub 2021 Oct 23. iScience. 2021. PMID: 34723157 Free PMC article. - Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation.
Gibson SE, Liu YC, Yatsenko SA, Barasch NJ, Swerdlow SH. Gibson SE, et al. Mod Pathol. 2022 Jan;35(1):60-68. doi: 10.1038/s41379-021-00938-z. Epub 2021 Oct 2. Mod Pathol. 2022. PMID: 34601504 - The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation.
Wang C, Mao X, Liu S, He C, Wang Y, Zhu L, Wang Y, Zhang Y. Wang C, et al. Case Rep Med. 2021 Jul 16;2021:9951122. doi: 10.1155/2021/9951122. eCollection 2021. Case Rep Med. 2021. PMID: 34326878 Free PMC article. - Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
Elsner RA, Shlomchik MJ. Elsner RA, et al. Immunity. 2020 Dec 15;53(6):1136-1150. doi: 10.1016/j.immuni.2020.11.006. Immunity. 2020. PMID: 33326765 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous