The immunological synapse: a molecular machine controlling T cell activation - PubMed (original) (raw)
The immunological synapse: a molecular machine controlling T cell activation
A Grakoui et al. Science. 1999.
Abstract
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.
Comment in
- Dancing the immunological two-step.
Malissen B. Malissen B. Science. 1999 Jul 9;285(5425):207-8. doi: 10.1126/science.285.5425.207. Science. 1999. PMID: 10428718 No abstract available.
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