The immunological synapse: a molecular machine controlling T cell activation - PubMed (original) (raw)
The immunological synapse: a molecular machine controlling T cell activation
A Grakoui et al. Science. 1999.
Abstract
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands. Initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.
Comment in
- Dancing the immunological two-step.
Malissen B. Malissen B. Science. 1999 Jul 9;285(5425):207-8. doi: 10.1126/science.285.5425.207. Science. 1999. PMID: 10428718 No abstract available.
Similar articles
- Dancing the immunological two-step.
Malissen B. Malissen B. Science. 1999 Jul 9;285(5425):207-8. doi: 10.1126/science.285.5425.207. Science. 1999. PMID: 10428718 No abstract available. - The immunological synapse balances T cell receptor signaling and degradation.
Lee KH, Dinner AR, Tu C, Campi G, Raychaudhuri S, Varma R, Sims TN, Burack WR, Wu H, Wang J, Kanagawa O, Markiewicz M, Allen PM, Dustin ML, Chakraborty AK, Shaw AS. Lee KH, et al. Science. 2003 Nov 14;302(5648):1218-22. doi: 10.1126/science.1086507. Epub 2003 Sep 25. Science. 2003. PMID: 14512504 - Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Choudhuri K, et al. Nature. 2014 Mar 6;507(7490):118-23. doi: 10.1038/nature12951. Epub 2014 Feb 2. Nature. 2014. PMID: 24487619 Free PMC article. - Impact of the immunological synapse on T cell signaling.
Dustin ML. Dustin ML. Results Probl Cell Differ. 2006;43:175-98. doi: 10.1007/400_019. Results Probl Cell Differ. 2006. PMID: 17068972 Review. - Information transfer at the immunological synapse.
Delon J, Germain RN. Delon J, et al. Curr Biol. 2000 Dec 14-28;10(24):R923-33. doi: 10.1016/s0960-9822(00)00870-8. Curr Biol. 2000. PMID: 11137031 Review.
Cited by
- Artificial antigen-presenting cell system reveals CD28's role in modulating T cell functions during human immunodeficiency virus infection.
Kabakibo TS, Arnold E, Padhan K, Lemieux A, Ortega-Delgado GG, Routy JP, Shoukry N, Dubé M, Kaufmann DE. Kabakibo TS, et al. iScience. 2024 Sep 13;27(10):110947. doi: 10.1016/j.isci.2024.110947. eCollection 2024 Oct 18. iScience. 2024. PMID: 39381752 Free PMC article. - Biomimetic cell stimulation with a graphene oxide antigen-presenting platform for developing T cell-based therapies.
Zhu E, Yu J, Li YR, Ma F, Wang YC, Liu Y, Li M, Kim YJ, Zhu Y, Hahn Z, Zhou Y, Brown J, Zhang Y, Pelegrini M, Hsiai T, Yang L, Huang Y. Zhu E, et al. Nat Nanotechnol. 2024 Sep 23. doi: 10.1038/s41565-024-01781-4. Online ahead of print. Nat Nanotechnol. 2024. PMID: 39313679 - 3D Printing as a Strategy to Scale-Up Biohybrid Hydrogels for T Cell Manufacture.
Pérez Del Río E, Rey-Vinolas S, Santos F, Castellote-Borrell M, Merlina F, Veciana J, Ratera I, Mateos-Timoneda MA, Engel E, Guasch J. Pérez Del Río E, et al. ACS Appl Mater Interfaces. 2024 Sep 25;16(38):50139-50146. doi: 10.1021/acsami.4c06183. Epub 2024 Sep 16. ACS Appl Mater Interfaces. 2024. PMID: 39285613 Free PMC article. - Both sides now: evolutionary traits of antigens and B cells in tolerance and activation.
Hong Y, Kwak K. Hong Y, et al. Front Immunol. 2024 Aug 9;15:1456220. doi: 10.3389/fimmu.2024.1456220. eCollection 2024. Front Immunol. 2024. PMID: 39185403 Free PMC article. Review. - Changes in Neuroimmunological Synapses During Cerebral Ischemia.
Bitar L, Puig B, Oertner TG, Dénes Á, Magnus T. Bitar L, et al. Transl Stroke Res. 2024 Aug 5. doi: 10.1007/s12975-024-01286-1. Online ahead of print. Transl Stroke Res. 2024. PMID: 39103660 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources