Abnormal cell calcium homeostasis in type 2 diabetes mellitus: a new look on old disease - PubMed (original) (raw)
Review
Abnormal cell calcium homeostasis in type 2 diabetes mellitus: a new look on old disease
J Levy. Endocrine. 1999 Feb.
Abstract
Cumulative evidence reveals that diabetes is a condition in which cell Ca2+ homeostasis is impaired. Defects in cell Ca2+ regulation were found in erythrocytes, cardiac muscle, platelets, skeletal muscle, kidney, aorta, adipocytes, liver, osteoblasts, arteries, lens, peripheral nerves, brain synaptosomes, retinal tissue, and pancreatic beta cells, confirming that this defect in cell Ca2+ metabolism is a basic pathology associated with the diabetic state. Though different defects in a variety of functions that regulate cell Ca2+ homeostasis were described in diabetes, the most common finding is an increase in [Ca2+]i levels. However, it is not clear whether the defect in cell Ca2+ metabolism in diabetes precedes or succeeds the overt diabetic condition. It is also not clear which of the multiple functions involved in cell Ca2+ regulation has the primary defect. Defects in cell Ca2+ metabolism may be significant for the observed pathologies in insulin secretion and insulin action in diabetes. They may also play an important role in the vascular complications seen in this condition, such as hypertension, atherosclerosis, and microangiopathy. Therefore, better understanding of the impairment in cell Ca2+ metabolism in diabetes may markedly enhance our understanding of this condition.
Similar articles
- Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension.
Levy J, Zemel MB, Sowers JR. Levy J, et al. Am J Med. 1989 Dec 8;87(6A):7S-16S. doi: 10.1016/0002-9343(89)90489-0. Am J Med. 1989. PMID: 2688414 Review. - Non-insulin-dependent diabetes-induced defects in cardiac cellular calcium regulation.
Allo SN, Lincoln TM, Wilson GL, Green FJ, Watanabe AM, Schaffer SW. Allo SN, et al. Am J Physiol. 1991 Jun;260(6 Pt 1):C1165-71. doi: 10.1152/ajpcell.1991.260.6.C1165. Am J Physiol. 1991. PMID: 1829324 - Intracellular calcium handling by fibroblasts from non-insulin dependent diabetic patients with and without hypertension and microalbuminuria.
Solini A, Di Virgilio F, Sfriso A, Bruseghin M, Crepaldi G, Nosadini R. Solini A, et al. Kidney Int. 1996 Aug;50(2):618-26. doi: 10.1038/ki.1996.357. Kidney Int. 1996. PMID: 8840294 - Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients.
Bouaziz A, Salido S, Linares-Palomino PJ, Sanchez A, Altarejos J, Bartegi A, Salido GM, Rosado JA. Bouaziz A, et al. Arch Biochem Biophys. 2007 Jan 15;457(2):235-42. doi: 10.1016/j.abb.2006.10.020. Epub 2006 Nov 7. Arch Biochem Biophys. 2007. PMID: 17118329 - Cardiomyopathy associated with noninsulin-dependent diabetes.
Schaffer SW. Schaffer SW. Mol Cell Biochem. 1991 Sep 18;107(1):1-20. doi: 10.1007/BF02424571. Mol Cell Biochem. 1991. PMID: 1664489 Review.
Cited by
- Calcium influx rapidly establishes distinct spatial recruitments of Annexins to cell wounds.
Nakamura M, Parkhurst SM. Nakamura M, et al. Genetics. 2024 Aug 7;227(4):iyae101. doi: 10.1093/genetics/iyae101. Genetics. 2024. PMID: 38874345 Free PMC article. - Environmental exposure to lead and cadmium are associated with triglyceride glucose index.
Jin T, Park EY, Kim B, Oh JK. Jin T, et al. Sci Rep. 2024 Jan 30;14(1):2496. doi: 10.1038/s41598-024-52994-5. Sci Rep. 2024. PMID: 38291186 Free PMC article. - Gene-diet interaction analysis using novel weighted food scores discovers the adipocytokine signaling pathway associated with the development of type 2 diabetes.
Apio C, Chung W, Moon MK, Kwon O, Park T. Apio C, et al. Front Endocrinol (Lausanne). 2023 Aug 23;14:1165744. doi: 10.3389/fendo.2023.1165744. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37680885 Free PMC article. - Recent Advances in In-Vitro Assays for Type 2 Diabetes Mellitus: An Overview.
Vhora N, Naskar U, Hiray A, Kate AS, Jain A. Vhora N, et al. Rev Diabet Stud. 2020;16(1):13-23. doi: 10.1900/RDS.2020.16.13. Epub 2020 Dec 28. Rev Diabet Stud. 2020. PMID: 33905469 Free PMC article. Review. - Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise.
Joseph A, Parvathy S, Varma KK. Joseph A, et al. J Diabetes Res. 2021 Feb 23;2021:5123241. doi: 10.1155/2021/5123241. eCollection 2021. J Diabetes Res. 2021. PMID: 33708999 Free PMC article.
References
- Coron Artery Dis. 1996 Feb;7(2):109-15 - PubMed
- Microvasc Res. 1980 Jan;19(1):108-26 - PubMed
- N Engl J Med. 1976 Aug 19;295(8):420-5 - PubMed
- Diabetes Metab Rev. 1988 Jun;4(4):339-70 - PubMed
- Am J Med. 1994 Mar;96(3):260-73 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous