Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism - PubMed (original) (raw)
Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism
S Malarkannan et al. Immunity. 1999 Jun.
Free article
Abstract
Immune surveillance by CD8 T cells requires that peptides derived from intracellular proteins be presented by MHC class I molecules on the target cell surface. Interestingly, MHC molecules can also present peptides encoded in alternate translational reading frames, some even without conventional AUG initiation codons. Using T cells to measure expression of MHC bound peptides, we identified the non-AUG translation initiation codons and established that their activity was at the level of translational rather than DNA replication or transcription mechanisms. This translation mechanism decoded the CUG initiation codon not as the canonical methionine but as the leucine residue, and its activity was independent of upstream translation initiation events. Naturally processed peptide/MHC complexes can thus arise from "noncoding" mRNAs via a novel translation initiation mechanism.
Similar articles
- Unanticipated antigens: translation initiation at CUG with leucine.
Schwab SR, Shugart JA, Horng T, Malarkannan S, Shastri N. Schwab SR, et al. PLoS Biol. 2004 Nov;2(11):e366. doi: 10.1371/journal.pbio.0020366. Epub 2004 Oct 26. PLoS Biol. 2004. PMID: 15510226 Free PMC article. - Constitutive display of cryptic translation products by MHC class I molecules.
Schwab SR, Li KC, Kang C, Shastri N. Schwab SR, et al. Science. 2003 Sep 5;301(5638):1367-71. doi: 10.1126/science.1085650. Science. 2003. PMID: 12958358 - Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I.
Starck SR, Jiang V, Pavon-Eternod M, Prasad S, McCarthy B, Pan T, Shastri N. Starck SR, et al. Science. 2012 Jun 29;336(6089):1719-23. doi: 10.1126/science.1220270. Science. 2012. PMID: 22745432 - Non-conventional sources of peptides presented by MHC class I.
Starck SR, Shastri N. Starck SR, et al. Cell Mol Life Sci. 2011 May;68(9):1471-9. doi: 10.1007/s00018-011-0655-0. Epub 2011 Mar 10. Cell Mol Life Sci. 2011. PMID: 21390547 Free PMC article. Review. - mRNA translation from an antigen presentation perspective: A tribute to the works of Nilabh Shastri.
Apcher S, Tovar-Fernadez M, Ducellier S, Thermou A, Nascimento M, Sroka E, Fahraeus R. Apcher S, et al. Mol Immunol. 2022 Jan;141:305-308. doi: 10.1016/j.molimm.2021.12.010. Epub 2021 Dec 15. Mol Immunol. 2022. PMID: 34920325 Review.
Cited by
- Molecular targets and strategies in the development of nucleic acid cancer vaccines: from shared to personalized antigens.
Chi WY, Hu Y, Huang HC, Kuo HH, Lin SH, Kuo CJ, Tao J, Fan D, Huang YM, Wu AA, Hung CF, Wu TC. Chi WY, et al. J Biomed Sci. 2024 Oct 9;31(1):94. doi: 10.1186/s12929-024-01082-x. J Biomed Sci. 2024. PMID: 39379923 Free PMC article. Review. - Tumor Antigens beyond the Human Exome.
Emilius L, Bremm F, Binder AK, Schaft N, Dörrie J. Emilius L, et al. Int J Mol Sci. 2024 Apr 25;25(9):4673. doi: 10.3390/ijms25094673. Int J Mol Sci. 2024. PMID: 38731892 Free PMC article. Review. - Codon-optimization in gene therapy: promises, prospects and challenges.
Paremskaia AI, Kogan AA, Murashkina A, Naumova DA, Satish A, Abramov IS, Feoktistova SG, Mityaeva ON, Deviatkin AA, Volchkov PY. Paremskaia AI, et al. Front Bioeng Biotechnol. 2024 Mar 28;12:1371596. doi: 10.3389/fbioe.2024.1371596. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38605988 Free PMC article. Review. - SOCS1 expression in cancer cells: potential roles in promoting antitumor immunity.
Ilangumaran S, Gui Y, Shukla A, Ramanathan S. Ilangumaran S, et al. Front Immunol. 2024 Feb 13;15:1362224. doi: 10.3389/fimmu.2024.1362224. eCollection 2024. Front Immunol. 2024. PMID: 38415248 Free PMC article. - eIF2A represses cell wall biogenesis gene expression in Saccharomyces cerevisiae.
Meyer L, Courtin B, Gomard M, Namane A, Permal E, Badis G, Jacquier A, Fromont-Racine M. Meyer L, et al. PLoS One. 2023 Nov 27;18(11):e0293228. doi: 10.1371/journal.pone.0293228. eCollection 2023. PLoS One. 2023. PMID: 38011112 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials