Isolation and partial characterization of a lentivirus from talapoin monkeys (Myopithecus talapoin) - PubMed (original) (raw)
. 1999 Jul 20;260(1):116-24.
doi: 10.1006/viro.1999.9794.
Affiliations
- PMID: 10405363
- DOI: 10.1006/viro.1999.9794
Free article
Isolation and partial characterization of a lentivirus from talapoin monkeys (Myopithecus talapoin)
A D Osterhaus et al. Virology. 1999.
Free article
Abstract
We have identified a novel lentivirus prevalent in talapoin monkeys (Myopithecus talapoin), extending previous observations of human immunodeficiency virus-1 cross-reactive antibodies in the serum of these monkeys. We obtained a virus isolate from one of three seropositive monkeys initially available to us. The virus was tentatively named simian immunodeficiency virus from talapoin monkeys (SIVtal). Despite the difficulty of isolating this virus, it was readily passed between monkeys in captivity through unknown routes of transmission. The virus could be propagated for short terms in peripheral blood mononuclear cells of talapoin monkeys but not in human peripheral blood mononuclear cells or human T cell lines. The propagated virus was used to infect a naive talapoin monkey, four rhesus macaques (M. mulatta), and two cynomolgus macaques (M. fascicularis). All animals seroconverted and virus could be reisolated during a short period after experimental infection. A survey of SIVtal-infected captive talapoin monkeys revealed a relative decrease in CD4(+) cell numbers in chronically (>2 years) infected animals. No other signs of immunodeficiency were observed in any of the infected animals. PCR amplification followed by DNA sequencing of two fragments of the polymerase gene revealed that SIVtal is different from the presently known lentiviruses and perhaps most related to the SIV from Sykes monkeys.
Copyright 1999 Academic Press.
Similar articles
- Molecular characterization of a novel simian immunodeficiency virus lineage (SIVtal) from northern talapoins (Miopithecus ogouensis).
Liegeois F, Courgnaud V, Switzer WM, Murphy HW, Loul S, Aghokeng A, Pourrut X, Mpoudi-Ngole E, Delaporte E, Peeters M. Liegeois F, et al. Virology. 2006 May 25;349(1):55-65. doi: 10.1016/j.virol.2006.01.011. Epub 2006 Feb 8. Virology. 2006. PMID: 16469345 - High viral load and CD4 lymphopenia in rhesus and cynomolgus macaques infected by a chimeric primate lentivirus constructed using the env, rev, tat, and vpu genes from HIV-1 Lai.
Dunn CS, Beyer C, Kieny MP, Gloeckler L, Schmitt D, Gut JP, Kirn A, Aubertin AM. Dunn CS, et al. Virology. 1996 Sep 15;223(2):351-61. doi: 10.1006/viro.1996.0486. Virology. 1996. PMID: 8806570 - Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.
Fomsgaard A, Hirsch VM, Johnson PR. Fomsgaard A, et al. Eur J Immunol. 1992 Nov;22(11):2973-81. doi: 10.1002/eji.1830221132. Eur J Immunol. 1992. PMID: 1425921 - A new look at HIV transmission from seropositive mothers to their infants: the facts beyond serology.
Jehuda-Cohen T. Jehuda-Cohen T. Isr J Med Sci. 1994 May-Jun;30(5-6):364-8. Isr J Med Sci. 1994. PMID: 8034484 Review.
Cited by
- So Pathogenic or So What?-A Brief Overview of SIV Pathogenesis with an Emphasis on Cure Research.
Kleinman AJ, Pandrea I, Apetrei C. Kleinman AJ, et al. Viruses. 2022 Jan 12;14(1):135. doi: 10.3390/v14010135. Viruses. 2022. PMID: 35062339 Free PMC article. Review. - Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.
Mandell DT, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek DC, Keele BF, Apetrei C, Pandrea I. Mandell DT, et al. J Virol. 2014 Jun;88(12):6778-92. doi: 10.1128/JVI.03785-13. Epub 2014 Apr 2. J Virol. 2014. PMID: 24696477 Free PMC article. - Metagenomics and future perspectives in virus discovery.
Mokili JL, Rohwer F, Dutilh BE. Mokili JL, et al. Curr Opin Virol. 2012 Feb;2(1):63-77. doi: 10.1016/j.coviro.2011.12.004. Epub 2012 Jan 20. Curr Opin Virol. 2012. PMID: 22440968 Free PMC article. Review. - Simian immunodeficiency virus SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivo.
Gautam R, Gaufin T, Butler I, Gautam A, Barnes M, Mandell D, Pattison M, Tatum C, Macfarland J, Monjure C, Marx PA, Pandrea I, Apetrei C. Gautam R, et al. J Virol. 2009 Aug;83(16):7894-908. doi: 10.1128/JVI.00444-09. Epub 2009 Jun 3. J Virol. 2009. PMID: 19493994 Free PMC article. - Consensus-degenerate hybrid oligonucleotide primers (CODEHOPs) for the detection of novel viruses in non-human primates.
Staheli JP, Ryan JT, Bruce AG, Boyce R, Rose TM. Staheli JP, et al. Methods. 2009 Sep;49(1):32-41. doi: 10.1016/j.ymeth.2009.05.011. Epub 2009 May 27. Methods. 2009. PMID: 19477279 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Research Materials