Attenuation of dopamine uptake in vivo following priming with estradiol benzoate - PubMed (original) (raw)
Attenuation of dopamine uptake in vivo following priming with estradiol benzoate
T L Thompson. Brain Res. 1999.
Abstract
Dopamine (DA) uptake and clearance were examined using in vivo voltammetry following injection of DA (200 microM) into the nucleus accumbens of ovariectomized (OVX) or OVX-estrogen-primed rats (estradiol benzoate, EB, 10 microg 48 and 24 h prior to experiment). The rate of DA uptake was significantly attenuated in steroid-treated animals: this decrease was accompanied by a significant increase in DA clearance time. Quinpirole (0.5 mg/kg) modulated the kinetics of DA uptake in OVX but not EB-primed rats. These data suggest that DA clearance can be regulated by physiological doses of EB.
Copyright 1999 Elsevier Science B.V.