The role of chemokines in the regulation of dendritic cell trafficking - PubMed (original) (raw)

Review

The role of chemokines in the regulation of dendritic cell trafficking

S Sozzani et al. J Leukoc Biol. 1999 Jul.

Abstract

The immunobiology of dendritic cells (DC) involves localization in tissues and trafficking via the lymph or blood to lymphoid organs. Appropriate assays representative of different steps of DC trafficking (e.g., reverse transmigration) provide the tools to dissect the migratory properties of these cells. Chemokines have emerged as important regulators of DC migration. DC are both the target and the source of chemokines. DC express receptors for and respond to a set of chemoattractants that overlap with, but are distinct from, those active on other leukocytes. Differential expression of the CCR6 receptor reveals heterogeneity among DC populations. Functional maturation is associated with loss of responsiveness to chemokines present at sites of inflammation and acquisition of a receptor repertoire that renders these cells responsive to signals that guide their localization in lymphoid organs. A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to up-regulate and orient specific immunity.

PubMed Disclaimer

Similar articles

• Control of dendritic cell migration by chemokines.
  Sozzani S, Mantovani A, Allavena P. Sozzani S, et al. Forum (Genova). 1999 Oct-Dec;9(4):325-38. Forum (Genova). 1999. PMID: 10611409 Review.
• Chemokines and dendritic cell traffic.
  Sozzani S, Allavena P, Vecchi A, Mantovani A. Sozzani S, et al. J Clin Immunol. 2000 May;20(3):151-60. doi: 10.1023/a:1006659211340. J Clin Immunol. 2000. PMID: 10941822 Review.
• In vitro studies on the trafficking of dendritic cells through endothelial cells and extra-cellular matrix.
  Bianchi G, D'Amico G, Varone L, Sozzani S, Mantovani A, Allavena P. Bianchi G, et al. Dev Immunol. 2000;7(2-4):143-53. doi: 10.1155/2000/39893. Dev Immunol. 2000. PMID: 11097208 Free PMC article.
• The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues.
  Allavena P, Sica A, Vecchi A, Locati M, Sozzani S, Mantovani A. Allavena P, et al. Immunol Rev. 2000 Oct;177:141-9. doi: 10.1034/j.1600-065x.2000.17714.x. Immunol Rev. 2000. PMID: 11138772 Review.
• Dendritic cell biology and regulation of dendritic cell trafficking by chemokines.
  Caux C, Ait-Yahia S, Chemin K, de Bouteiller O, Dieu-Nosjean MC, Homey B, Massacrier C, Vanbervliet B, Zlotnik A, Vicari A. Caux C, et al. Springer Semin Immunopathol. 2000;22(4):345-69. doi: 10.1007/s002810000053. Springer Semin Immunopathol. 2000. PMID: 11155441 Review.

Cited by

• The Spectrum of CAR Cellular Effectors: Modes of Action in Anti-Tumor Immunity.
  Nguyen NTT, Müller R, Briukhovetska D, Weber J, Feucht J, Künkele A, Hudecek M, Kobold S. Nguyen NTT, et al. Cancers (Basel). 2024 Jul 22;16(14):2608. doi: 10.3390/cancers16142608. Cancers (Basel). 2024. PMID: 39061247 Free PMC article. Review.
• Tanimilast, A Novel Inhaled Pde4 Inhibitor for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease.
  Facchinetti F, Civelli M, Singh D, Papi A, Emirova A, Govoni M. Facchinetti F, et al. Front Pharmacol. 2021 Nov 23;12:740803. doi: 10.3389/fphar.2021.740803. eCollection 2021. Front Pharmacol. 2021. PMID: 34887752 Free PMC article. Review.
• Impaired Dendritic Cell Homing in COVID-19.
  Borcherding L, Teksen AS, Grosser B, Schaller T, Hirschbühl K, Claus R, Spring O, Wittmann M, Römmele C, Sipos É, Märkl B. Borcherding L, et al. Front Med (Lausanne). 2021 Nov 4;8:761372. doi: 10.3389/fmed.2021.761372. eCollection 2021. Front Med (Lausanne). 2021. PMID: 34805226 Free PMC article.
• CCR4 is a prognostic biomarker and correlated with immune infiltrates in head and neck squamous cell carcinoma.
  Zhang Y, Chen K, Li L, Mao W, Shen D, Yao N, Zhang L. Zhang Y, et al. Ann Transl Med. 2021 Sep;9(18):1443. doi: 10.21037/atm-21-3936. Ann Transl Med. 2021. PMID: 34733995 Free PMC article.
• Interleukin-6, CXCL10 and Infiltrating Macrophages in COVID-19-Related Cytokine Storm: Not One for All But All for One!
  Coperchini F, Chiovato L, Rotondi M. Coperchini F, et al. Front Immunol. 2021 Apr 26;12:668507. doi: 10.3389/fimmu.2021.668507. eCollection 2021. Front Immunol. 2021. PMID: 33981314 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database