Nitrite reductase activity is a novel function of mammalian mitochondria - PubMed (original) (raw)
Nitrite reductase activity is a novel function of mammalian mitochondria
A V Kozlov et al. FEBS Lett. 1999.
Free article
Abstract
Nitrite, which is the major stable degradation product of nitric oxide, exists in all tissues capable of nitric oxide synthesis from L-arginine. The present study provides experimental evidence that nitrite in contact with respiring mitochondria accepts reducing equivalents from the ubiquinone cycle of the respiratory chain. Univalent reduction of nitrite was totally inhibited by myxothiazol. We therefore conclude on the involvement of redox cycling that ubisemiquinone is associated with the bc1 complex. Recycling of nitric oxide degradation products via these electron carriers may become a threat to energy-linked respiration since nitric oxide in direct contact with mitochondria was shown to slow the energy-linked respiration down and to trigger a mitochondrial source for superoxide radicals. Until now, the existence of nitrite reductase activity was only demonstrated in plants and bacteria. In addition, the present observation elucidates the existence of a nitric oxide synthase-independent nitric oxide source.
Similar articles
- Mitochondria recycle nitrite back to the bioregulator nitric monoxide.
Nohl H, Staniek K, Sobhian B, Bahrami S, Redl H, Kozlov AV. Nohl H, et al. Acta Biochim Pol. 2000;47(4):913-21. Acta Biochim Pol. 2000. PMID: 11996114 - NO-synthase and nitrite-reductase components of nitric oxide cycle.
Reutov VP, Sorokina EG. Reutov VP, et al. Biochemistry (Mosc). 1998 Jul;63(7):874-84. Biochemistry (Mosc). 1998. PMID: 9721340 Review. - Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2.
Sparacino-Watkins CE, Tejero J, Sun B, Gauthier MC, Thomas J, Ragireddy V, Merchant BA, Wang J, Azarov I, Basu P, Gladwin MT. Sparacino-Watkins CE, et al. J Biol Chem. 2014 Apr 11;289(15):10345-10358. doi: 10.1074/jbc.M114.555177. Epub 2014 Feb 5. J Biol Chem. 2014. PMID: 24500710 Free PMC article. - Biochemical predetermination of the NO synthase and nitrite reductase components of the nitric oxide cycle.
Reutov VP. Reutov VP. Biochemistry (Mosc). 1999 May;64(5):528-42. Biochemistry (Mosc). 1999. PMID: 10381613 Review.
Cited by
- Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension.
Montenegro MF, Pinheiro LC, Amaral JH, Marçal DM, Palei AC, Costa-Filho AJ, Tanus-Santos JE. Montenegro MF, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):509-17. doi: 10.1007/s00210-011-0712-0. Epub 2012 Jan 20. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22262021 - Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases.
Maia LB, Moura JJ. Maia LB, et al. J Biol Inorg Chem. 2015 Mar;20(2):403-33. doi: 10.1007/s00775-014-1234-2. Epub 2015 Jan 15. J Biol Inorg Chem. 2015. PMID: 25589250 Review. - Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly.
Torregrossa AC, Aranke M, Bryan NS. Torregrossa AC, et al. J Geriatr Cardiol. 2011 Dec;8(4):230-42. doi: 10.3724/SP.J.1263.2011.00230. J Geriatr Cardiol. 2011. PMID: 22783310 Free PMC article. - The impact of biosampling procedures on molecular data interpretation.
Sköld K, Alm H, Scholz B. Sköld K, et al. Mol Cell Proteomics. 2013 Jun;12(6):1489-501. doi: 10.1074/mcp.R112.024869. Epub 2013 Feb 4. Mol Cell Proteomics. 2013. PMID: 23382104 Free PMC article. Review. - Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide.
Kollau A, Hofer A, Russwurm M, Koesling D, Keung WM, Schmidt K, Brunner F, Mayer B. Kollau A, et al. Biochem J. 2005 Feb 1;385(Pt 3):769-77. doi: 10.1042/BJ20041354. Biochem J. 2005. PMID: 15377279 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources