The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels - PubMed (original) (raw)
Review
The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels
B Santoro et al. Ann N Y Acad Sci. 1999.
Abstract
The molecular basis of the hyperpolarization-activated cation channels that underlie the anomalous rectifying current variously termed Ih, Iq, or I(f) is discussed. On the basis of the expression patterns and biophysical properties of the newly cloned HCN ion channels, an initial attempt at defining the identity and subunit composition of channels underlying native Ih is undertaken. By comparing the sequences of HCN channels to other members of the K channel superfamily, we discuss how channel opening may be coupled to membrane hyperpolarization and to direct binding of cyclic nucleotide. Finally, we consider some of the questions in cardiovascular physiology and neurobiology that can be addressed as a result of the demonstration that Ih is encoded by the HCN gene family.
Similar articles
- Hyperpolarization-activated cation currents: from molecules to physiological function.
Robinson RB, Siegelbaum SA. Robinson RB, et al. Annu Rev Physiol. 2003;65:453-80. doi: 10.1146/annurev.physiol.65.092101.142734. Epub 2002 Nov 19. Annu Rev Physiol. 2003. PMID: 12471170 Review. - Molecular diversity of pacemaker ion channels.
Kaupp UB, Seifert R. Kaupp UB, et al. Annu Rev Physiol. 2001;63:235-57. doi: 10.1146/annurev.physiol.63.1.235. Annu Rev Physiol. 2001. PMID: 11181956 Review. - Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide.
Chen S, Wang J, Siegelbaum SA. Chen S, et al. J Gen Physiol. 2001 May;117(5):491-504. doi: 10.1085/jgp.117.5.491. J Gen Physiol. 2001. PMID: 11331358 Free PMC article. - Cardiac HCN channels: structure, function, and modulation.
Biel M, Schneider A, Wahl C. Biel M, et al. Trends Cardiovasc Med. 2002 Jul;12(5):206-12. doi: 10.1016/s1050-1738(02)00162-7. Trends Cardiovasc Med. 2002. PMID: 12161074 Review. - Hyperpolarization-activated, cyclic AMP-gated, HCN1-like cation channel: the primary, full-length HCN isoform expressed in a saccular hair-cell layer.
Cho WJ, Drescher MJ, Hatfield JS, Bessert DA, Skoff RP, Drescher DG. Cho WJ, et al. Neuroscience. 2003;118(2):525-34. doi: 10.1016/s0306-4522(02)00913-2. Neuroscience. 2003. PMID: 12699787
Cited by
- Feasibility of Short-Term Use of Ivabradine in Critical Ill Patients Who Have Atrial Fibrillation and Tachycardia.
Lin WC, Peng PS, Lin SL. Lin WC, et al. Acta Cardiol Sin. 2024 Jul;40(4):373-382. doi: 10.6515/ACS.202407_40(4).20240411A. Acta Cardiol Sin. 2024. PMID: 39045379 Free PMC article. - Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development.
Li H, Tang Q, Yang T, Wang Z, Li D, Wang L, Li L, Chen Y, Huang H, Zhang Y, Chen Y. Li H, et al. Commun Biol. 2024 Mar 29;7(1):385. doi: 10.1038/s42003-024-06039-2. Commun Biol. 2024. PMID: 38553636 Free PMC article. - The Dysfunction of Ca2+ Channels in Hereditary and Chronic Human Heart Diseases and Experimental Animal Models.
Shemarova I. Shemarova I. Int J Mol Sci. 2023 Oct 27;24(21):15682. doi: 10.3390/ijms242115682. Int J Mol Sci. 2023. PMID: 37958665 Free PMC article. Review. - Ih current stabilizes excitability in rodent DRG neurons and reverses hyperexcitability in a nociceptive neuron model of inherited neuropathic pain.
Vasylyev DV, Liu S, Waxman SG. Vasylyev DV, et al. J Physiol. 2023 Dec;601(23):5341-5366. doi: 10.1113/JP284999. Epub 2023 Oct 17. J Physiol. 2023. PMID: 37846879 - The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis.
Zhao K, Li Y, Yang X, Zhou L. Zhao K, et al. Curr Neuropharmacol. 2023;21(10):2070-2078. doi: 10.2174/1570159X21666230214110333. Curr Neuropharmacol. 2023. PMID: 37366350 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources