Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration - PubMed (original) (raw)
Comparative Study
. 1999 Jul 15;59(14):3340-5.
Affiliations
- PMID: 10416590
Comparative Study
Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration
A A Eggert et al. Cancer Res. 1999.
Abstract
Dendritic cells (DCs) are professional antigen-presenting cells, well equipped to initiate an immune response. Currently, tumor antigen-derived peptide loaded DCs are used in clinical vaccination in cancer patients. However, the optimal dose and route of administration of a DC vaccine still remain to be determined. Using indium-111-labeled DCs, we investigated whether the route of administration does affect the biodistribution of DCs in lymphoid organs and whether it influences the outcome of DC vaccination in the B16 mouse melanoma tumor model. The results demonstrate that i.v. injected DCs mainly accumulate in the spleen, whereas s.c. injected DCs preferentially home to the T-cell areas of the draining lymph nodes. Using tyrosinase-related protein-2-derived peptide-loaded DC vaccination in a fully autologous B16 melanoma tumor model, we observed a delay in tumor growth, improved survival as well as increased antitumor cytotoxic T-cell reactivity after s.c. vaccination as compared to i.v. vaccination. These data demonstrate that optimal induction of antitumor reactivity against the autologous melanocyte differentiation antigen tyrosinase-related protein-2-derived peptide occurs after s.c. vaccination and correlates with the preferential accumulation of DCs in the T-cell areas of lymph nodes.
Similar articles
- Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity.
Tüting T, Steitz J, Brück J, Gambotto A, Steinbrink K, DeLeo AB, Robbins P, Knop J, Enk AH. Tüting T, et al. J Gene Med. 1999 Nov-Dec;1(6):400-6. doi: 10.1002/(SICI)1521-2254(199911/12)1:6<400::AID-JGM68>3.0.CO;2-D. J Gene Med. 1999. PMID: 10753065 - Eliciting T cell immunity against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines.
Wang J, Saffold S, Cao X, Krauss J, Chen W. Wang J, et al. J Immunol. 1998 Nov 15;161(10):5516-24. J Immunol. 1998. PMID: 9820528 - Administration route-dependent vaccine efficiency of murine dendritic cells pulsed with antigens.
Okada N, Tsujino M, Hagiwara Y, Tada A, Tamura Y, Mori K, Saito T, Nakagawa S, Mayumi T, Fujita T, Yamamoto A. Okada N, et al. Br J Cancer. 2001 Jun 1;84(11):1564-70. doi: 10.1054/bjoc.2001.1801. Br J Cancer. 2001. PMID: 11384109 Free PMC article. - Dendritic cell gene therapy.
Onaitis M, Kalady MF, Pruitt S, Tyler DS. Onaitis M, et al. Surg Oncol Clin N Am. 2002 Jul;11(3):645-60. doi: 10.1016/s1055-3207(02)00027-3. Surg Oncol Clin N Am. 2002. PMID: 12487060 Review. - Dendritic cell-based vaccines for the therapy of experimental tumors.
Pajtasz-Piasecka E, Indrová M. Pajtasz-Piasecka E, et al. Immunotherapy. 2010 Mar;2(2):257-68. doi: 10.2217/imt.10.7. Immunotherapy. 2010. PMID: 20635932 Review.
Cited by
- Dendritic cell vaccination combined with irreversible electroporation for treating pancreatic cancer-a narrative review.
Zhang Z, Yu G, Eresen A, Chen Z, Yu Z, Yaghmai V, Zhang Z. Zhang Z, et al. Ann Transl Med. 2024 Aug 1;12(4):77. doi: 10.21037/atm-23-1882. Epub 2024 May 28. Ann Transl Med. 2024. PMID: 39118942 Free PMC article. Review. - Cancer vaccines in the clinic.
Janes ME, Gottlieb AP, Park KS, Zhao Z, Mitragotri S. Janes ME, et al. Bioeng Transl Med. 2023 Oct 27;9(1):e10588. doi: 10.1002/btm2.10588. eCollection 2024 Jan. Bioeng Transl Med. 2023. PMID: 38193112 Free PMC article. Review. - Challenges in tolerogenic dendritic cell therapy for autoimmune diseases: the route of administration.
Mansilla MJ, Hilkens CMU, Martínez-Cáceres EM. Mansilla MJ, et al. Immunother Adv. 2023 Jul 18;3(1):ltad012. doi: 10.1093/immadv/ltad012. eCollection 2023. Immunother Adv. 2023. PMID: 37546348 Free PMC article. Review. - Magnetic Particle Imaging Is a Sensitive In Vivo Imaging Modality for the Detection of Dendritic Cell Migration.
Gevaert JJ, Fink C, Dikeakos JD, Dekaban GA, Foster PJ. Gevaert JJ, et al. Mol Imaging Biol. 2022 Dec;24(6):886-897. doi: 10.1007/s11307-022-01738-w. Epub 2022 Jun 1. Mol Imaging Biol. 2022. PMID: 35648316 - Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging.
Gawne PJ, Man F, Blower PJ, T M de Rosales R. Gawne PJ, et al. Chem Rev. 2022 Jun 8;122(11):10266-10318. doi: 10.1021/acs.chemrev.1c00767. Epub 2022 May 12. Chem Rev. 2022. PMID: 35549242 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources