The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila - PubMed (original) (raw)
. 1999 Jul 15;400(6741):276-80.
doi: 10.1038/22336.
K Kamimura, H Nakato, M Archer, W Staatz, B Fox, M Humphrey, S Olson, T Futch, V Kaluza, E Siegfried, L Stam, S B Selleck
Affiliations
- PMID: 10421371
- DOI: 10.1038/22336
The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
M Tsuda et al. Nature. 1999.
Abstract
Wingless (Wg) is a member of the Wnt family of growth factors, secreted proteins that control proliferation and differentiation during development. Studies in Drosophila have shown that responses to Wg require cell-surface heparan sulphate, a glycosaminoglycan component of proteoglycans. These findings suggest that a cell-surface proteoglycan is a component of a Wg/Wnt receptor complex. We demonstrate here that the protein encoded by the division abnormally delayed (dally) gene is a cell-surface, heparan-sulphate-modified proteoglycan. dally partial loss-of-function mutations compromise Wg-directed events, and disruption of dally function with RNA interference produces phenotypes comparable to those found with RNA interference of wg or frizzled (fz)/Dfz2. Ectopic expression of Dally potentiates Wg signalling without altering levels of Wg and can rescue a wg partial loss-of-function mutant. We also show that dally, a regulator of Decapentaplegic (Dpp) signalling during post-embryonic development, has tissue-specific effects on Wg and Dpp signalling. Dally can therefore differentially influence signalling mediated by two growth factors, and may form a regulatory component of both Wg and Dpp receptor complexes.
Comment in
- Signal transduction. Neither straight nor narrow.
Peifer M. Peifer M. Nature. 1999 Jul 15;400(6741):213-5. doi: 10.1038/22214. Nature. 1999. PMID: 10421354 No abstract available.
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