Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes - PubMed (original) (raw)
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Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes
S T Qureshi et al. Trends Genet. 1999 Aug.
Abstract
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.
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