Behavioural effects of amphetamine in a small primate: relative potencies of the d- and l-isomers - PubMed (original) (raw)

Comparative Study

. 1978 Dec 8;59(3):243-5.

doi: 10.1007/BF00426628.

• PMID: 104327
• DOI: 10.1007/BF00426628

Comparative Study

Behavioural effects of amphetamine in a small primate: relative potencies of the d- and l-isomers

P R Scraggs et al. Psychopharmacology (Berl). 1978.

Abstract

Acute administration of d-amphetamine (up to 8 mg/kg) or l-amphetamine (up to 12 mg/kg) in the marmoset results in a dose-dependent increase in small head movements (checking), an almost total suppression of activities including eating, grooming, playing, and social interaction, but little change in the amount of movement. Severe stereotypy is seen at high doses of both isomers. The d-isomer has approximately twice the potency of the l-isomer in increasing checking behaviour.

PubMed Disclaimer

Similar articles

• The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset.
  Scraggs PR, Ridley RM. Scraggs PR, et al. Psychopharmacology (Berl). 1979 Mar 29;62(1):41-5. doi: 10.1007/BF00426033. Psychopharmacology (Berl). 1979. PMID: 155838
• Modification of the behavioural effects of amphetamine by a GABA agonist in a primate species.
  Ridley RM, Scraggs PR, Baker HF. Ridley RM, et al. Psychopharmacology (Berl). 1979 Aug 8;64(2):197-200. doi: 10.1007/BF00496062. Psychopharmacology (Berl). 1979. PMID: 115041
• The behavioural effects of (+)-amphetamine and apomorphine in the marmoset [proceedings].
  Ridley RM, Crow TJ. Ridley RM, et al. Br J Pharmacol. 1978 Mar;62(3):393P. Br J Pharmacol. 1978. PMID: 416868 Free PMC article. No abstract available.
• The time course of the behavioral effects of amphetamine and their reversal by haloperidol in a primate species.
  Ridley RM, Baker HF, Scraggs PR. Ridley RM, et al. Biol Psychiatry. 1979 Oct;14(5):753-65. Biol Psychiatry. 1979. PMID: 115505
• Stereotypy in monkeys and humans.
  Ridley RM, Baker HF. Ridley RM, et al. Psychol Med. 1982 Feb;12(1):61-72. doi: 10.1017/s0033291700043294. Psychol Med. 1982. PMID: 6805001 Review.

Cited by

• 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates.
  Iravani MM, Jackson MJ, Kuoppamäki M, Smith LA, Jenner P. Iravani MM, et al. J Neurosci. 2003 Oct 8;23(27):9107-15. doi: 10.1523/JNEUROSCI.23-27-09107.2003. J Neurosci. 2003. PMID: 14534244 Free PMC article.
• Pharmacologic manipulations of brain catecholamines and the behavior of Callithrix jacchus (marmoset).
  Campos F, Arruda F. Campos F, et al. Psychopharmacology (Berl). 1981;73(3):252-6. doi: 10.1007/BF00422412. Psychopharmacology (Berl). 1981. PMID: 6787644
• Social withdrawal following amphetamine administration to marmosets.
  Annett LE, Ridley RM, Gamble SJ, Baker HF. Annett LE, et al. Psychopharmacology (Berl). 1989;99(2):222-9. doi: 10.1007/BF00442812. Psychopharmacology (Berl). 1989. PMID: 2508158
• Behavioural effects of intracerebral amphetamine in the marmoset.
  Annett LE, Ridley RM, Gamble SJ, Baker HF. Annett LE, et al. Psychopharmacology (Berl). 1983;81(1):18-23. doi: 10.1007/BF00439267. Psychopharmacology (Berl). 1983. PMID: 6415726 No abstract available.
• The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset.
  Scraggs PR, Ridley RM. Scraggs PR, et al. Psychopharmacology (Berl). 1979 Mar 29;62(1):41-5. doi: 10.1007/BF00426033. Psychopharmacology (Berl). 1979. PMID: 155838

References

1. 1. Psychopharmacologia. 1967;11(4):300-10 - PubMed
2. 1. Eur J Pharmacol. 1972 Apr;18(1):63-73 - PubMed
3. 1. Biochem Pharmacol. 1976 Feb 15;25(4):447-51 - PubMed
4. 1. J Pharmacol Exp Ther. 1969 Dec;170(2):221-31 - PubMed
5. 1. Science. 1970 Jun 19;168(3938):1487-9 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer