A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34 - PubMed (original) (raw)
A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34
N Hiraoka et al. Immunity. 1999 Jul.
Free article
Abstract
L-selectin mediates lymphocyte homing by facilitating lymphocyte adhesion to unique carbohydrate ligands, sulfated sialyl Lewis(x), which are expressed on high endothelial venules (HEV) in secondary lymphoid organs. The nature of the sulfotransferase(s) that contribute to sulfation of such L-selectin counterreceptors has been uncertain. We herein describe a novel L-selectin ligand sulfotransferase, termed LSST, that directs the synthesis of the 6-sulfo sialyl Lewis(x) on L-selectin counterreceptors CD34, GlyCAM-1, and MAdCAM-1. LSST is predominantly expressed in HEV and exhibits striking catalytic preference for core 2-branched mucin-type O-glycans as found in natural L-selectin counterreceptors. LSST enhances L-selectin-mediated adhesion under shear compared to nonsulfated controls. LSST therefore corresponds to an HEV-specific sulfotransferase that contributes to the biosynthesis of L-selectin ligands required for lymphocyte homing.
Similar articles
- Core 2 branching beta1,6-N-acetylglucosaminyltransferase and high endothelial venule-restricted sulfotransferase collaboratively control lymphocyte homing.
Hiraoka N, Kawashima H, Petryniak B, Nakayama J, Mitoma J, Marth JD, Lowe JB, Fukuda M. Hiraoka N, et al. J Biol Chem. 2004 Jan 23;279(4):3058-67. doi: 10.1074/jbc.M311150200. Epub 2003 Oct 30. J Biol Chem. 2004. PMID: 14593101 - Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing.
Hiraoka N, Petryniak B, Kawashima H, Mitoma J, Akama TO, Fukuda MN, Lowe JB, Fukuda M. Hiraoka N, et al. Glycobiology. 2007 Mar;17(3):277-93. doi: 10.1093/glycob/cwl077. Epub 2006 Dec 15. Glycobiology. 2007. PMID: 17172261 - Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.
Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S. Bistrup A, et al. J Cell Biol. 1999 May 17;145(4):899-910. doi: 10.1083/jcb.145.4.899. J Cell Biol. 1999. PMID: 10330415 Free PMC article. - Biosynthesis of sulfated L-selectin ligands in human high endothelial venules (HEV).
Girard JP, Amalric F. Girard JP, et al. Adv Exp Med Biol. 1998;435:55-62. doi: 10.1007/978-1-4615-5383-0_6. Adv Exp Med Biol. 1998. PMID: 9498065 Review. - Role of sulfated O-glycans expressed by high endothelial venule-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseases.
Kobayashi M, Fukuda M, Nakayama J. Kobayashi M, et al. Biol Pharm Bull. 2009 May;32(5):774-9. doi: 10.1248/bpb.32.774. Biol Pharm Bull. 2009. PMID: 19420741 Free PMC article. Review.
Cited by
- GlcNAc6ST-1-mediated decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates directs disease activity of ulcerative colitis.
Kobayashi M, Hoshino H, Masumoto J, Fukushima M, Suzawa K, Kageyama S, Suzuki M, Ohtani H, Fukuda M, Nakayama J. Kobayashi M, et al. Inflamm Bowel Dis. 2009 May;15(5):697-706. doi: 10.1002/ibd.20827. Inflamm Bowel Dis. 2009. PMID: 19067429 Free PMC article. - Role of MAdCAM-1-Expressing High Endothelial Venule-Like Vessels in Colitis Induced in Mice Lacking Sulfotransferases Catalyzing L-Selectin Ligand Biosynthesis.
Low S, Hirakawa J, Hoshino H, Uchimura K, Kawashima H, Kobayashi M. Low S, et al. J Histochem Cytochem. 2018 Jun;66(6):415-425. doi: 10.1369/0022155417753363. Epub 2018 Jan 19. J Histochem Cytochem. 2018. PMID: 29350564 Free PMC article. - GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated _N_-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium.
Takeda-Uchimura Y, Ikezaki M, Akama TO, Ihara Y, Allain F, Nishitsuji K, Uchimura K. Takeda-Uchimura Y, et al. Molecules. 2024 Feb 7;29(4):764. doi: 10.3390/molecules29040764. Molecules. 2024. PMID: 38398516 Free PMC article. - Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.
Yu SY, Hsiao CT, Izawa M, Yusa A, Ishida H, Nakamura S, Yagi H, Kannagi R, Khoo KH. Yu SY, et al. J Biol Chem. 2018 Sep 28;293(39):15163-15177. doi: 10.1074/jbc.RA118.001937. Epub 2018 Aug 9. J Biol Chem. 2018. PMID: 30093410 Free PMC article. - Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides.
Ohyama C, Kanto S, Kato K, Nakano O, Arai Y, Kato T, Chen S, Fukuda MN, Fukuda M. Ohyama C, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13789-94. doi: 10.1073/pnas.212456599. Epub 2002 Oct 7. Proc Natl Acad Sci U S A. 2002. PMID: 12370411 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous