Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats - PubMed (original) (raw)
Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats
I M Matos et al. Eur J Pharmacol. 1999.
Abstract
In cases of severe human scorpion envenoming, lung injury is a common finding and frequently the cause of death. In the rat, two distinct mechanisms account for oedema following the intravenous injection of the venom -- acute left ventricular failure resulting from a massive release of catecholamines and an increase in pulmonary vascular permeability. In the present work, we investigated the effects of a tachykinin NK1 receptor antagonist (CP96,345, the dihydrochloride salt of (2S,3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-az abicycol[2.2.2]octan-3-amine) and its 2 R-3 R inactive enantiomer (CP96,344) on the acute lung injury induced by the i.v. injection of Tityus serrulatus venom in rats. Lung injury was assessed by evaluating the extravasation of Evans blue dye in the bronchoalveolar lavage fluid and in the lung of venom-treated and control animals. The effects of the platelet-activating factor (PAF) receptor antagonist WEB2170 (2-methyl-1-phenylimidazol[4,5c]pyridine) were evaluated for comparison. The i.v. injection of the venom induced the extravasation of Evans blue in the bronchoalveolar lavage fluid and into the left lung. Pretreament with the tachykinin NK1 receptor antagonist CP96,345, but not CP96,344, inhibited Evans blue dye extravasation in the bronchoalveolar lavage fluid and in the lung by 96% and 86%, respectively. The PAF receptor antagonist WEB2170 inhibited the increase in vascular permeability in the bronchoalveolar lavage fluid by 60% and had no effect on the extravasation to the lung parenchyma of venom-injected animals. In addition to abrogating lung injury, pretreatment of rats with CP96,345, but not CP96,344 or WEB2170, decreased by 70% the mortality induced by the venom. This is the first study to show the relevance of the tachykinin NK1 receptor in mediating lung injury and mortality in animals injected with the neurotoxic T. serrulatus venom. Blockade of the tachykinin NK1 receptor may represent an important strategy in the treatment of patients with signs of severe envenoming and clearly deserves further studies.
Similar articles
- Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum.
Matos IM, Teixeira MM, Leite R, Freire-Maia L. Matos IM, et al. Eur J Pharmacol. 1999 Mar 5;368(2-3):231-6. doi: 10.1016/s0014-2999(99)00016-3. Eur J Pharmacol. 1999. PMID: 10193659 - Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat.
Borges CM, Silveira MR, Aparecida M, Beker CL, Freire-Maia L, Teixeira MM. Borges CM, et al. J Leukoc Biol. 2000 Apr;67(4):515-9. doi: 10.1002/jlb.67.4.515. J Leukoc Biol. 2000. PMID: 10770284 - Alleviation of wood smoke-induced lung injury by tachykinin receptor antagonist and hydroxyl radical scavenger in guinea pigs.
Lin YS, Ho CY, Tang GJ, Kou YR. Lin YS, et al. Eur J Pharmacol. 2001 Aug 10;425(2):141-8. doi: 10.1016/s0014-2999(01)01184-0. Eur J Pharmacol. 2001. PMID: 11502280 - Androctonus australis hector venom contributes to the interaction between neuropeptides and mast cells in pulmonary hyperresponsiveness.
Chaïr-Yousfi I, Laraba-Djebari F, Hammoudi-Triki D. Chaïr-Yousfi I, et al. Int Immunopharmacol. 2015 Mar;25(1):19-29. doi: 10.1016/j.intimp.2015.01.008. Epub 2015 Jan 16. Int Immunopharmacol. 2015. PMID: 25601496 - Evidence for a role of capsaicin-sensitive sensory nerves in the lung oedema induced by Tityus serrulatus venom in rats.
Andrade MV, Souza DG, de A Castro MS, Cunha-Melo JR, Teixeira MM. Andrade MV, et al. Toxicon. 2002 Mar;40(3):283-7. doi: 10.1016/s0041-0101(01)00224-0. Toxicon. 2002. PMID: 11711125
Cited by
- Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice.
de Paula TP, Santos PC, Arifa RDDN, Vieira AT, Baltazar LM, Ávila TV, Fagundes CT, Garcia ZM, Lima RL, Teixeira MM, Souza DG. de Paula TP, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00764-17. doi: 10.1128/AAC.00764-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29463546 Free PMC article. - Role of the bradykinin B2 receptor for the local and systemic inflammatory response that follows severe reperfusion injury.
Souza DG, Pinho V, Pesquero JL, Lomez ES, Poole S, Juliano L, Correa A Jr, de A Castro MS, Teixeira MM. Souza DG, et al. Br J Pharmacol. 2003 May;139(1):129-39. doi: 10.1038/sj.bjp.0705200. Br J Pharmacol. 2003. PMID: 12746231 Free PMC article. - Mast Cells Modulate the Immune Response and Redox Status of the Gastrointestinal Tract in Induced Venom Pathogenesis.
Zerarka-Chabane N, Laraba-Djebari F, Hammoudi-Triki D. Zerarka-Chabane N, et al. Inflammation. 2022 Apr;45(2):509-527. doi: 10.1007/s10753-021-01562-4. Epub 2021 Oct 5. Inflammation. 2022. PMID: 34608585 - Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat.
Souza DG, Cara DC, Cassali GD, Coutinho SF, Silveira MR, Andrade SP, Poole SP, Teixeira MM. Souza DG, et al. Br J Pharmacol. 2000 Dec;131(8):1800-8. doi: 10.1038/sj.bjp.0703756. Br J Pharmacol. 2000. PMID: 11139461 Free PMC article. - Role of the platelet-activating factor (PAF) receptor during pulmonary infection with gram negative bacteria.
Soares AC, Pinho VS, Souza DG, Shimizu T, Ishii S, Nicoli JR, Teixeira MM. Soares AC, et al. Br J Pharmacol. 2002 Nov;137(5):621-8. doi: 10.1038/sj.bjp.0704918. Br J Pharmacol. 2002. PMID: 12381675 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources