Integrating bits and pieces: synapse structure and formation in Drosophila embryos - PubMed (original) (raw)
Review
. 1999 Aug;297(2):169-86.
doi: 10.1007/s004410051345.
Affiliations
- PMID: 10470487
- DOI: 10.1007/s004410051345
Review
Integrating bits and pieces: synapse structure and formation in Drosophila embryos
A Prokop. Cell Tissue Res. 1999 Aug.
Abstract
During the development of the nervous system, numerous neurons connect to form complex networks. In order to build a functional network each neuron has to establish contacts with appropriate target cells, and at these contacts synapses of the right quality and strength have to be formed. Gaining insight into the mechanisms underlying this complex development is an important step towards a better understanding of how the nervous system is formed and behaviour generated. One model system in which synapse formation can be studied at the morphological, physiological and molecular level is that of the fruitfly Drosophila, and insights gained from Drosophila embryos are reviewed here. The first part of this review deals with the neuromuscular junction as the best-known synaptic contact in Drosophila. It describes: (1) its structure, (2) mechanisms underlying the formation of the neuromuscular cell junction and the arborisation of the presynaptic terminal, and (3) our present understanding of signal-dependent and -independent processes during synapse formation at the neuromuscular junction. The last part of this review deals with the question of how particular neurons can adopt specific synaptic properties, stating as an example the development of the neural lineage of NB7-3, which gives rise to two serotonergic neurons.
Similar articles
- Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones.
Prokop A, Landgraf M, Rushton E, Broadie K, Bate M. Prokop A, et al. Neuron. 1996 Oct;17(4):617-26. doi: 10.1016/s0896-6273(00)80195-6. Neuron. 1996. PMID: 8893020 - In Vivo Calcium Signaling during Synaptic Refinement at the Drosophila Neuromuscular Junction.
Vonhoff F, Keshishian H. Vonhoff F, et al. J Neurosci. 2017 May 31;37(22):5511-5526. doi: 10.1523/JNEUROSCI.2922-16.2017. Epub 2017 May 5. J Neurosci. 2017. PMID: 28476946 Free PMC article. - Synaptic development: insights from Drosophila.
Collins CA, DiAntonio A. Collins CA, et al. Curr Opin Neurobiol. 2007 Feb;17(1):35-42. doi: 10.1016/j.conb.2007.01.001. Epub 2007 Jan 16. Curr Opin Neurobiol. 2007. PMID: 17229568 Review. - Activity-dependent development of the neuromuscular synapse during Drosophila embryogenesis.
Broadie K, Bate M. Broadie K, et al. Neuron. 1993 Oct;11(4):607-19. doi: 10.1016/0896-6273(93)90073-z. Neuron. 1993. PMID: 7691105 - Embryonic and larval neural connectivity: progressive changes in synapse form and function at the neuromuscular junction mediated by cytoskeletal regulation.
Long JB, Van Vactor D. Long JB, et al. Wiley Interdiscip Rev Dev Biol. 2013 Nov-Dec;2(6):747-65. doi: 10.1002/wdev.114. Epub 2013 Mar 15. Wiley Interdiscip Rev Dev Biol. 2013. PMID: 24123935 Review.
Cited by
- Drosophila Glia: Models for Human Neurodevelopmental and Neurodegenerative Disorders.
Kim T, Song B, Lee IS. Kim T, et al. Int J Mol Sci. 2020 Jul 9;21(14):4859. doi: 10.3390/ijms21144859. Int J Mol Sci. 2020. PMID: 32660023 Free PMC article. Review. - Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles.
Itoh K, Akimoto Y, Kondo S, Ichimiya T, Aoki K, Tiemeyer M, Nishihara S. Itoh K, et al. Dev Biol. 2018 Apr 15;436(2):108-124. doi: 10.1016/j.ydbio.2018.02.017. Epub 2018 Feb 27. Dev Biol. 2018. PMID: 29499182 Free PMC article. - Transcellular Nanoalignment of Synaptic Function.
Biederer T, Kaeser PS, Blanpied TA. Biederer T, et al. Neuron. 2017 Nov 1;96(3):680-696. doi: 10.1016/j.neuron.2017.10.006. Neuron. 2017. PMID: 29096080 Free PMC article. Review. - Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.
Petralia RS, Wang YX, Mattson MP, Yao PJ. Petralia RS, et al. Neuromolecular Med. 2017 Sep;19(2-3):193-240. doi: 10.1007/s12017-017-8445-y. Epub 2017 Jun 13. Neuromolecular Med. 2017. PMID: 28612182 Free PMC article. Review. - Three-dimensional imaging of Drosophila motor synapses reveals ultrastructural organizational patterns.
Zhan H, Bruckner J, Zhang Z, O'Connor-Giles K. Zhan H, et al. J Neurogenet. 2016 Sep-Dec;30(3-4):237-246. doi: 10.1080/01677063.2016.1253693. J Neurogenet. 2016. PMID: 27981875 Free PMC article.