Long-term potentiation--a decade of progress? - PubMed (original) (raw)

Review

Long-term potentiation--a decade of progress?

R C Malenka et al. Science. 1999.

Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

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