Evaluation of genetic, common-litter, and within-litter effects on preweaning mortality in a birth cohort of puppies - PubMed (original) (raw)
. 1999 Sep;60(9):1106-10.
Affiliations
- PMID: 10490080
Evaluation of genetic, common-litter, and within-litter effects on preweaning mortality in a birth cohort of puppies
S van der Beek et al. Am J Vet Res. 1999 Sep.
Abstract
Objective: To determine relative impact of genetic, common-litter, and within-litter factors on puppy mortality.
Animals: 2,622 Boxer puppies of 413 litters born during a 14-month period.
Procedure: For each puppy, pedigree was determined, and litter in which it was born was registered. Overall mortality and mortality per specific cause of death were analyzed by use of a model that included an additive genetic effect, common-litter effect, within-litter effect, and regression of mortality on inbreeding coefficient. Relative importance of the effects was determined from estimates of the variance in mortality explained by each factor.
Results: 22% of the puppies died before reaching 7 weeks old. Stillbirth was the most frequent cause of death, followed by infection. Most observed differences were attributable to within-litter factors, which explained 67% of the variance in death attributable to infection and < or = 96% of the variance in death attributable to asphyxia. Common-litter factors were more important than additive genetic factors. Variance attributed to common-litter factors ranged from 2% for cheiloschisis, palatoschisis, or cheilopalatoschisis to 30% for death attributable to infection, and variance attributed to additive genetic factors ranged from 0% for asphyxia to 14% for euthanatized because of white color. Inbreeding coefficient had a significant effect on death attributable to infection, which increased 0.26% for each percentage increase of inbreeding.
Conclusions and clinical relevance: Additive genetic factors have less impact on preweaning mortality than common-litter factors, which in turn have less impact than within-litter factors. Mortality attributable to infection increases significantly with increases in inbreeding.
Similar articles
- [Influence of inbreeding on litter size and the proportion of stillborn puppies in dachshunds].
Gresky C, Hamann H, Distl O. Gresky C, et al. Berl Munch Tierarztl Wochenschr. 2005 Mar-Apr;118(3-4):134-9. Berl Munch Tierarztl Wochenschr. 2005. PMID: 15803761 German. - [Population genetic analysis of the new dog breed Elo].
Kaufhold J, Hamann H, Distl O. Kaufhold J, et al. Berl Munch Tierarztl Wochenschr. 2005 Jan-Feb;118(1-2):67-75. Berl Munch Tierarztl Wochenschr. 2005. PMID: 15690637 German. - [Genetic and epidemiological investigation of a birth cohort of boxers].
Nielen AL, Knol BW, van Hagen MA, van der Gaag I. Nielen AL, et al. Tijdschr Diergeneeskd. 2003 Oct 1;128(19):586-90. Tijdschr Diergeneeskd. 2003. PMID: 14582319 Dutch. - Cesarean section on request at 39 weeks: impact on shoulder dystocia, fetal trauma, neonatal encephalopathy, and intrauterine fetal demise.
Hankins GD, Clark SM, Munn MB. Hankins GD, et al. Semin Perinatol. 2006 Oct;30(5):276-87. doi: 10.1053/j.semperi.2006.07.009. Semin Perinatol. 2006. PMID: 17011400 Review. - The most common congenital malformations in dogs: Literature review and practical guide.
Estevam MV, Toniollo GH, Apparicio M. Estevam MV, et al. Res Vet Sci. 2024 May;171:105230. doi: 10.1016/j.rvsc.2024.105230. Epub 2024 Mar 13. Res Vet Sci. 2024. PMID: 38492280 Review.
Cited by
- Refining the APGAR Score Cutoff Values and Viability Classes According to Breed Body Size in Newborn Dogs.
Veronesi MC, Faustini M, Probo M, Rota A, Fusi J. Veronesi MC, et al. Animals (Basel). 2022 Jun 28;12(13):1664. doi: 10.3390/ani12131664. Animals (Basel). 2022. PMID: 35804563 Free PMC article. - Population Structure Analysis of the Border Collie Dog Breed in Hungary.
Ács V, Bokor Á, Nagy I. Ács V, et al. Animals (Basel). 2019 May 16;9(5):250. doi: 10.3390/ani9050250. Animals (Basel). 2019. PMID: 31100978 Free PMC article. - What can cohort studies in the dog tell us?
Pugh CA, Bronsvoort BM, Handel IG, Summers KM, Clements DN. Pugh CA, et al. Canine Genet Epidemiol. 2014 May 15;1:5. doi: 10.1186/2052-6687-1-5. eCollection 2014. Canine Genet Epidemiol. 2014. PMID: 26401322 Free PMC article. Review. - Inbreeding and fertility in Irish Wolfhounds in Sweden: 1976 to 2007.
Urfer SR. Urfer SR. Acta Vet Scand. 2009 May 6;51(1):21. doi: 10.1186/1751-0147-51-21. Acta Vet Scand. 2009. PMID: 19419574 Free PMC article. - The Swedish breeding cat: population description, infectious diseases and reproductive performance evaluated by a questionnaire.
Ström Holst B, Frössling J. Ström Holst B, et al. J Feline Med Surg. 2009 Oct;11(10):793-802. doi: 10.1016/j.jfms.2009.01.008. Epub 2009 Feb 28. J Feline Med Surg. 2009. PMID: 19254857 Free PMC article.