Serum markers of brain damage and outcome prediction in patients after severe head injury - PubMed (original) (raw)
Serum markers of brain damage and outcome prediction in patients after severe head injury
A Raabe et al. Br J Neurosurg. 1999 Feb.
Abstract
The objective of the study was to investigate the validity of outcome prediction after severe head injury using serum levels of S-100B protein and neuron specific enolase. Eighty-two patients with severe head injury were included in this prospective study. Venous blood samples were taken after admission and every 24 h for a maximum of 10 consecutive days. For values of S-100 from 0 to 2.5 micrograms/l, and for values of NSE from 0 to 100 micrograms/l the sensitivity and specificity of incremental values as a predictor of unfavourable outcome were calculated and Receiver Operator Characteristics curves were plotted. Serum S-100 protein was found to be clearly superior to neuron specific enolase in terms of predicting outcome with higher specificity, sensitivity, positive and negative predictive value. According to our experience, S-100B protein represents the most promising serum marker of brain cell damage currently under investigation.
Similar articles
- Correlation of computed tomography findings and serum brain damage markers following severe head injury.
Raabe A, Grolms C, Keller M, Döhnert J, Sorge O, Seifert V. Raabe A, et al. Acta Neurochir (Wien). 1998;140(8):787-91; discussion 791-2. doi: 10.1007/s007010050180. Acta Neurochir (Wien). 1998. PMID: 9810445 - S-100B and neuron specific enolase in outcome prediction of severe head injury.
Li N, Shen JK, Zhao WG, Cai Y, Li YF, Zhan SK. Li N, et al. Chin J Traumatol. 2004 Jun;7(3):156-8. Chin J Traumatol. 2004. PMID: 15294113 - Serum S-100B protein in severe head injury.
Raabe A, Grolms C, Sorge O, Zimmermann M, Seifert V. Raabe A, et al. Neurosurgery. 1999 Sep;45(3):477-83. doi: 10.1097/00006123-199909000-00012. Neurosurgery. 1999. PMID: 10493369 - Brain damage markers in children. Neurobiological and clinical aspects.
Leviton A, Dammann O. Leviton A, et al. Acta Paediatr. 2002;91(1):9-13. doi: 10.1080/080352502753457851. Acta Paediatr. 2002. PMID: 11883827 Review. - Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics.
Kövesdi E, Lückl J, Bukovics P, Farkas O, Pál J, Czeiter E, Szellár D, Dóczi T, Komoly S, Büki A. Kövesdi E, et al. Acta Neurochir (Wien). 2010 Jan;152(1):1-17. doi: 10.1007/s00701-009-0463-6. Epub 2009 Aug 4. Acta Neurochir (Wien). 2010. PMID: 19652904 Review.
Cited by
- Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity.
Thelin EP, Jeppsson E, Frostell A, Svensson M, Mondello S, Bellander BM, Nelson DW. Thelin EP, et al. Crit Care. 2016 Sep 8;20:285. doi: 10.1186/s13054-016-1450-y. Crit Care. 2016. PMID: 27604350 Free PMC article. - Reliability of S100B in predicting severity of central nervous system injury.
Bloomfield SM, McKinney J, Smith L, Brisman J. Bloomfield SM, et al. Neurocrit Care. 2007;6(2):121-38. doi: 10.1007/s12028-007-0008-x. Neurocrit Care. 2007. PMID: 17522796 Review. - Serum neuron-specific enolase as a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury.
Guzel A, Er U, Tatli M, Aluclu U, Ozkan U, Duzenli Y, Satici O, Guzel E, Kemaloglu S, Ceviz A, Kaplan A. Guzel A, et al. Neurosurg Rev. 2008 Oct;31(4):439-44; discussion 444-5. doi: 10.1007/s10143-008-0148-2. Epub 2008 Jun 17. Neurosurg Rev. 2008. PMID: 18560914 Clinical Trial. - Could Intrathymic Injection of Myelin Basic Protein Suppress Inflammatory Response After Co-culture of T Lymphocytes and BV-2 Microglia Cells?
Cui ZQ, Liu BL, Wu QL, Cai Y, Fan WJ, Zhang MC, Ding WL, Zhang B, Kang JM, Yan H. Cui ZQ, et al. Chin Med J (Engl). 2016 Apr 5;129(7):831-7. doi: 10.4103/0366-6999.178955. Chin Med J (Engl). 2016. PMID: 26996480 Free PMC article. - Biomarkers in the clinical diagnosis and management of traumatic brain injury.
Hergenroeder GW, Redell JB, Moore AN, Dash PK. Hergenroeder GW, et al. Mol Diagn Ther. 2008;12(6):345-58. doi: 10.1007/BF03256301. Mol Diagn Ther. 2008. PMID: 19035622
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous