Universal and unique features of kinesin motors: insights from a comparison of fungal and animal conventional kinesins - PubMed (original) (raw)
Review
. 1999 Jul-Aug;380(7-8):915-21.
doi: 10.1515/BC.1999.113.
Affiliations
- PMID: 10494842
- DOI: 10.1515/BC.1999.113
Free article
Review
Universal and unique features of kinesin motors: insights from a comparison of fungal and animal conventional kinesins
J Kirchner et al. Biol Chem. 1999 Jul-Aug.
Free article
Abstract
Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules. The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively towards the plus end of microtubules. Within the family of conventional kinesins, two groups can be distinguished to date, one derived from animal species, and one originating from filamentous fungi. So far no conventional kinesin has been reported from plant cells. Fungal and animal conventional kinesins differ in several respects, both in terms of their primary sequence and their physiological properties. Thus all fungal conventional kinesins move at velocities that are 4-5 times higher than those of animal conventional kinesins, and all of them appear to lack associated light chains. Both groups of motors are characterized by a number of group-specific sequence features which are considered here with respect to their functional importance. Animal and fungal conventional kinesins also share a number of sequence characteristics which point to common principles of motor function. The overall domain organization is remarkably similar. A C-terminal sequence motif common to all kinesins, which constitutes the only region of high homology outside the motor domain, suggests common principles of cargo association in both groups of motors. Consideration of the differences of, and similarities between, fungal and animal kinesins offers novel possibilities for experimentation (e. g., by constructing chimeras) that can be expected to contribute to our understanding of motor function.
Similar articles
- Cloning and functional expression of a 'fast' fungal kinesin.
Grummt M, Pistor S, Lottspeich F, Schliwa M. Grummt M, et al. FEBS Lett. 1998 May 1;427(1):79-84. doi: 10.1016/s0014-5793(98)00399-8. FEBS Lett. 1998. PMID: 9613604 - Properties of the Kinesin-1 motor DdKif3 from Dictyostelium discoideum.
Röhlk C, Rohlfs M, Leier S, Schliwa M, Liu X, Parsch J, Woehlke G. Röhlk C, et al. Eur J Cell Biol. 2008 Apr;87(4):237-49. doi: 10.1016/j.ejcb.2007.11.001. Epub 2007 Dec 21. Eur J Cell Biol. 2008. PMID: 18160177 - Structural links to kinesin directionality and movement.
Wade RH, Kozielski F. Wade RH, et al. Nat Struct Biol. 2000 Jun;7(6):456-60. doi: 10.1038/75850. Nat Struct Biol. 2000. PMID: 10881190 Review. - Kin I kinesins: insights into the mechanism of depolymerization.
Hertzer KM, Ems-McClung SC, Walczak CE. Hertzer KM, et al. Crit Rev Biochem Mol Biol. 2003;38(6):453-69. doi: 10.1080/10409230390267419. Crit Rev Biochem Mol Biol. 2003. PMID: 14695126 - Review: regulation mechanisms of Kinesin-1.
Adio S, Reth J, Bathe F, Woehlke G. Adio S, et al. J Muscle Res Cell Motil. 2006;27(2):153-60. doi: 10.1007/s10974-005-9054-1. Epub 2006 Feb 1. J Muscle Res Cell Motil. 2006. PMID: 16450053 Review.
Cited by
- Armadillo repeat-containing kinesin represents the versatile plus-end-directed transporter in Physcomitrella.
Yoshida MW, Hakozaki M, Goshima G. Yoshida MW, et al. Nat Plants. 2023 May;9(5):733-748. doi: 10.1038/s41477-023-01397-x. Epub 2023 May 4. Nat Plants. 2023. PMID: 37142749 - Cytokinesis in Trypanosoma brucei relies on an orphan kinesin that dynamically crosslinks microtubules.
Sladewski TE, Campbell PC, Billington N, D'Ordine A, Cole JL, de Graffenried CL. Sladewski TE, et al. Curr Biol. 2023 Mar 13;33(5):899-911.e5. doi: 10.1016/j.cub.2023.01.035. Epub 2023 Feb 13. Curr Biol. 2023. PMID: 36787745 Free PMC article. - Kinesin Motors in the Filamentous Basidiomycetes in Light of the Schizophyllum commune Genome.
Raudaskoski M. Raudaskoski M. J Fungi (Basel). 2022 Mar 12;8(3):294. doi: 10.3390/jof8030294. J Fungi (Basel). 2022. PMID: 35330296 Free PMC article. Review. - The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline.
Williams LS, Ganguly S, Loiseau P, Ng BF, Palacios IM. Williams LS, et al. Development. 2014 Jan;141(1):176-86. doi: 10.1242/dev.097592. Epub 2013 Nov 20. Development. 2014. PMID: 24257625 Free PMC article. - Single molecule mechanics of the kinesin neck.
Bornschlögl T, Woehlke G, Rief M. Bornschlögl T, et al. Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):6992-7. doi: 10.1073/pnas.0812620106. Epub 2009 Apr 14. Proc Natl Acad Sci U S A. 2009. PMID: 19369199 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical