Bacterial mechanosensitive channels: integrating physiology, structure and function - PubMed (original) (raw)
Review
Bacterial mechanosensitive channels: integrating physiology, structure and function
P Blount et al. Trends Microbiol. 1999 Oct.
Abstract
When confronted with hypo-osmotic stress, many bacterial species are able rapidly to adapt to the increase in cell turgor pressure by jettisoning cytoplasmic solutes into the medium through membrane-tension-gated channels. Physiological studies have confirmed the importance of these channels in osmoregulation. Mutagenesis of one of these channels, combined with structural information derived from X-ray crystallography, has given the first clues of how a mechanosensitive channel senses and responds to membrane tension.
Comment in
- Pulling the channel in many dimensions.
Sukharev I. Sukharev I. Trends Microbiol. 2000 Jan;8(1):12-3. doi: 10.1016/s0966-842x(99)01653-4. Trends Microbiol. 2000. PMID: 10637638 No abstract available.
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