Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? - PubMed (original) (raw)
Review
Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?
A L Mellor et al. Immunol Today. 1999 Oct.
Abstract
Some macrophages inhibit microbial infections by producing indoleamine 2,3 dioxygenase (IDO), which catabolizes tryptophan. Here, Andrew Mellor and David Munn discuss evidence that cells that synthesize IDO protect the mammalian fetus from maternal T-cell attack and argue that this mechanism might have wider implications for the control of T-cell responses.
Comment in
- Tryptophan degradation to control T-cell responsiveness.
Widner B, Weiss G, Fuchs D. Widner B, et al. Immunol Today. 2000 May;21(5):250. doi: 10.1016/s0167-5699(00)01616-9. Immunol Today. 2000. PMID: 10782059 No abstract available.
Similar articles
- Extinguishing maternal immune responses during pregnancy: implications for immunosuppression.
Mellor AL, Munn DH. Mellor AL, et al. Semin Immunol. 2001 Aug;13(4):213-8. doi: 10.1006/smim.2000.0317. Semin Immunol. 2001. PMID: 11437628 Review. - Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses.
Mellor AL, Munn DH. Mellor AL, et al. J Reprod Immunol. 2001 Oct-Nov;52(1-2):5-13. doi: 10.1016/s0165-0378(01)00118-8. J Reprod Immunol. 2001. PMID: 11600174 Review. - IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Mellor AL, Munn DH. Mellor AL, et al. Nat Rev Immunol. 2004 Oct;4(10):762-74. doi: 10.1038/nri1457. Nat Rev Immunol. 2004. PMID: 15459668 Review. - Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy.
Mellor AL, Chandler P, Lee GK, Johnson T, Keskin DB, Lee J, Munn DH. Mellor AL, et al. J Reprod Immunol. 2002 Oct-Nov;57(1-2):143-50. doi: 10.1016/s0165-0378(02)00040-2. J Reprod Immunol. 2002. PMID: 12385839 Review. - Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy.
Mellor AL, Sivakumar J, Chandler P, Smith K, Molina H, Mao D, Munn DH. Mellor AL, et al. Nat Immunol. 2001 Jan;2(1):64-8. doi: 10.1038/83183. Nat Immunol. 2001. PMID: 11135580
Cited by
- The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection.
Makala LH. Makala LH. J Biomed Sci. 2012 Jan 9;19(1):5. doi: 10.1186/1423-0127-19-5. J Biomed Sci. 2012. PMID: 22230608 Free PMC article. - The soluble CTLA-4 receptor and its role in autoimmune diseases: an update.
Saverino D, Simone R, Bagnasco M, Pesce G. Saverino D, et al. Auto Immun Highlights. 2010 Nov 4;1(2):73-81. doi: 10.1007/s13317-010-0011-7. eCollection 2010 Nov. Auto Immun Highlights. 2010. PMID: 26000110 Free PMC article. Review. - Mechanisms of malignant glioma immune resistance and sources of immunosuppression.
Gomez GG, Kruse CA. Gomez GG, et al. Gene Ther Mol Biol. 2006;10(A):133-146. Gene Ther Mol Biol. 2006. PMID: 16810329 Free PMC article. - Increased level of arginase activity correlates with disease severity in HIV-seropositive patients.
Cloke TE, Garvey L, Choi BS, Abebe T, Hailu A, Hancock M, Kadolsky U, Bangham CR, Munder M, Müller I, Taylor GP, Kropf P. Cloke TE, et al. J Infect Dis. 2010 Aug 15;202(3):374-85. doi: 10.1086/653736. J Infect Dis. 2010. PMID: 20575659 Free PMC article. - Escape from immunotherapy: possible mechanisms that influence tumor regression/progression.
Ahmad M, Rees RC, Ali SA. Ahmad M, et al. Cancer Immunol Immunother. 2004 Oct;53(10):844-54. doi: 10.1007/s00262-004-0540-x. Epub 2004 Jun 10. Cancer Immunol Immunother. 2004. PMID: 15197495 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials