Inflammatory responses to amyloid fibrils - PubMed (original) (raw)
Inflammatory responses to amyloid fibrils
S L Yates et al. Methods Enzymol. 1999.
Abstract
Our laboratory has routinely used the methodologies described here to characterize the effects of fibrillar A beta and amylin on cytokine synthesis and secretion by LPS-differentiated THP-1 cells. Because LPS-treated THP-1 cells resemble macrophage and microglia, this assay system represents an in vitro model of the potential interactions between A beta-containing senile plaques and microglia in the AD brain. As such, these methodologies should prove useful in the identification of compounds that inhibit this A beta-induced inflammatory response.
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