Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death - PubMed (original) (raw)

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

L Van Parijs et al. Immunity. 1999 Sep.

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Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Van Parijs L, et al. Immunity. 2009 Apr 17;30(4):611. doi: 10.1016/j.immuni.2009.04.002. Immunity. 2009. PMID: 19382300 No abstract available.

Abstract

IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). The molecular basis of these different effects of IL-2 was studied by introducing wild-type and mutant forms of the IL-2 receptor beta (IL-2Rbeta) chain that lacked specific signaling capacities into receptor-deficient T cells by retroviral gene transfer. Activation of Stat5 by IL-2 was found to be involved in T cell proliferation and promoted Fas ligand (FasL) expression and AICD. T cell survival was dependent on a receptor region that activated Akt and the expression of Bcl-2. Thus, distinct IL-2Rbeta chain signaling modules regulate T cell fate by stimulating growth and survival or by promoting apoptosis.

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Findings of scientific misconduct.
[No authors listed] [No authors listed] NIH Guide Grants Contracts. 2009 Jan 30:NOT-OD-09-040. NIH Guide Grants Contracts. 2009. PMID: 19186376 Free PMC article. No abstract available.

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death - PubMed (original) (raw)