TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction - PubMed (original) (raw)
. 1999 Oct 15;274(42):30202-8.
doi: 10.1074/jbc.274.42.30202.
P Mehlen, S Rabizadeh, T VanArsdale, H Zhang, H Shin, J J Wang, E Leo, J Zapata, C A Hauser, J C Reed, D E Bredesen
Affiliations
- PMID: 10514511
- DOI: 10.1074/jbc.274.42.30202
Free article
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
X Ye et al. J Biol Chem. 1999.
Free article
Abstract
The common neurotrophin receptor, p75(NTR), has been shown to signal in the absence of Trk tyrosine kinase receptors, including induction of neural apoptosis and activation of NF-kappaB. However, the mechanisms by which p75(NTR) initiates these intracellular signal transduction pathways are unknown. Here we report interactions between p75(NTR) and the six members of TRAF (tumor necrosis factor receptor-associated factors) family proteins. The binding of different TRAF proteins to p75(NTR) was mapped to distinct regions in p75(NTR). Furthermore, TRAF4 interacted with dimeric p75(NTR), whereas TRAF2 interacted preferentially with monomeric p75(NTR). TRAF2-p75(NTR), TRAF4-p75(NTR), and TRAF6-p75(NTR) interactions modulated p75(NTR)-induced cell death and NF-kappaB activation with contrasting effects. Coexpression of TRAF2 with p75(NTR) enhanced cell death, whereas coexpression of TRAF6 was cytoprotective. Furthermore, overexpression of TRAF4 abrogated the ability of dimerization to prevent the induction of apoptosis normally mediated by monomeric p75(NTR). TRAF4 also inhibited the NF-kappaB response, whereas TRAF2 and TRAF6 enhanced p75(NTR)-induced NF-kappaB activation. These results demonstrate that TRAF family proteins interact with p75(NTR) and differentially modulate its NF-kappaB activation and cell death induction.
Similar articles
- Association of the p75 neurotrophin receptor with TRAF6.
Khursigara G, Orlinick JR, Chao MV. Khursigara G, et al. J Biol Chem. 1999 Jan 29;274(5):2597-600. doi: 10.1074/jbc.274.5.2597. J Biol Chem. 1999. PMID: 9915784 - Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.
Leo E, Welsh K, Matsuzawa S, Zapata JM, Kitada S, Mitchell RS, Ely KR, Reed JC. Leo E, et al. J Biol Chem. 1999 Aug 6;274(32):22414-22. doi: 10.1074/jbc.274.32.22414. J Biol Chem. 1999. PMID: 10428814 - Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.
Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA. Irie S, et al. FEBS Lett. 1999 Oct 29;460(2):191-8. doi: 10.1016/s0014-5793(99)01324-1. FEBS Lett. 1999. PMID: 10544233 - Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily.
Vilar M. Vilar M. Vitam Horm. 2017;104:57-87. doi: 10.1016/bs.vh.2016.10.007. Epub 2016 Nov 29. Vitam Horm. 2017. PMID: 28215307 Review. - Dual role for p75(NTR) signaling in survival and cell death: can intracellular mediators provide an explanation?
Mamidipudi V, Wooten MW. Mamidipudi V, et al. J Neurosci Res. 2002 May 15;68(4):373-84. doi: 10.1002/jnr.10244. J Neurosci Res. 2002. PMID: 11992464 Review.
Cited by
- Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation.
Danelon V, Garret-Thomson SC, Almo SC, Lee FS, Hempstead BL. Danelon V, et al. Front Mol Neurosci. 2023 Dec 1;16:1305574. doi: 10.3389/fnmol.2023.1305574. eCollection 2023. Front Mol Neurosci. 2023. PMID: 38106879 Free PMC article. - Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases.
Numakawa T, Kajihara R. Numakawa T, et al. Front Mol Neurosci. 2023 Sep 14;16:1247422. doi: 10.3389/fnmol.2023.1247422. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37781095 Free PMC article. Review. - Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer's Disease.
Numakawa T, Kajihara R. Numakawa T, et al. Life (Basel). 2023 Feb 26;13(3):647. doi: 10.3390/life13030647. Life (Basel). 2023. PMID: 36983803 Free PMC article. Review. - TNF Receptor Associated Factor 2 (TRAF2) Signaling in Cancer.
Siegmund D, Wagner J, Wajant H. Siegmund D, et al. Cancers (Basel). 2022 Aug 22;14(16):4055. doi: 10.3390/cancers14164055. Cancers (Basel). 2022. PMID: 36011046 Free PMC article. Review. - The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
Numakawa T, Odaka H. Numakawa T, et al. Int J Mol Sci. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726. Int J Mol Sci. 2022. PMID: 35887075 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials