Bacteriocins: mechanism of membrane insertion and pore formation - PubMed (original) (raw)

Review

. 1999 Jul-Nov;76(1-4):185-98.

Affiliations

• PMID: 10532378

Review

Bacteriocins: mechanism of membrane insertion and pore formation

G N Moll et al. Antonie Van Leeuwenhoek. 1999 Jul-Nov.

Abstract

Lactic acid bacteria produce several types of pore forming peptides. Class I bacteriocins are lantibiotics that contain (methyl)lanthionine residues that may form intramolecular thioether rings. These peptides generally have a broad spectrum of activity and form unstable pores. Class II bacteriocins are small, heat stable peptides mostly with a narrow spectrum of activity. Most bacteriocins interact with anionic lipids that are abundantly present in the membranes of gram-positive bacteria. 'Docking molecules' may enhance the conductivity and stability of lantibiotic pores, while 'receptors' in the target membrane may determine specificity of class II bacteriocins. Insertion into the membrane of many bacteriocins is proton motive force driven. Lantibiotics may form pores according to a 'wedge-like' model, while class II bacteriocins may enhance membrane permeability either by the formation of a 'barrel stave' pore or by a 'carpet' mechanism.

PubMed Disclaimer

Similar articles

• Antimicrobial mechanism of lantibiotics.
  Islam MR, Nagao J, Zendo T, Sonomoto K. Islam MR, et al. Biochem Soc Trans. 2012 Dec 1;40(6):1528-33. doi: 10.1042/BST20120190. Biochem Soc Trans. 2012. PMID: 23176511 Review.
• Posttranslationally modified bacteriocins--the lantibiotics.
  Guder A, Wiedemann I, Sahl HG. Guder A, et al. Biopolymers. 2000;55(1):62-73. doi: 10.1002/1097-0282(2000)55:1<62::AID-BIP60>3.0.CO;2-Y. Biopolymers. 2000. PMID: 10931442 Review.
• The two-peptide class II bacteriocins: structure, production, and mode of action.
  Oppegård C, Rogne P, Emanuelsen L, Kristiansen PE, Fimland G, Nissen-Meyer J. Oppegård C, et al. J Mol Microbiol Biotechnol. 2007;13(4):210-9. doi: 10.1159/000104750. J Mol Microbiol Biotechnol. 2007. PMID: 17827971 Review.
• Mode of action of modified and unmodified bacteriocins from Gram-positive bacteria.
  Héchard Y, Sahl HG. Héchard Y, et al. Biochimie. 2002 May-Jun;84(5-6):545-57. doi: 10.1016/s0300-9084(02)01417-7. Biochimie. 2002. PMID: 12423799 Review.
• Peptide signal molecules and bacteriocins in Gram-negative bacteria: a genome-wide in silico screening for peptides containing a double-glycine leader sequence and their cognate transporters.
  Dirix G, Monsieurs P, Dombrecht B, Daniels R, Marchal K, Vanderleyden J, Michiels J. Dirix G, et al. Peptides. 2004 Sep;25(9):1425-40. doi: 10.1016/j.peptides.2003.10.028. Peptides. 2004. PMID: 15374646 Review.

Cited by

• Common mechanisms of target cell recognition and immunity for class II bacteriocins.
  Diep DB, Skaugen M, Salehian Z, Holo H, Nes IF. Diep DB, et al. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2384-9. doi: 10.1073/pnas.0608775104. Epub 2007 Feb 6. Proc Natl Acad Sci U S A. 2007. PMID: 17284603 Free PMC article.
• Biochemical and genetic characterization of propionicin T1, a new bacteriocin from Propionibacterium thoenii.
  Faye T, Langsrud T, Nes IF, Holo H. Faye T, et al. Appl Environ Microbiol. 2000 Oct;66(10):4230-6. doi: 10.1128/AEM.66.10.4230-4236.2000. Appl Environ Microbiol. 2000. PMID: 11010864 Free PMC article.
• Bacteriocins from Lactobacillus plantarum - production, genetic organization and mode of action: produção, organização genética e modo de ação.
  Todorov SD. Todorov SD. Braz J Microbiol. 2009 Apr;40(2):209-21. doi: 10.1590/S1517-83822009000200001. Epub 2009 Jun 1. Braz J Microbiol. 2009. PMID: 24031346 Free PMC article.
• Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink.
  Wilson MZ, Wang R, Gitai Z, Seyedsayamdost MR. Wilson MZ, et al. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1630-5. doi: 10.1073/pnas.1518034113. Epub 2016 Jan 22. Proc Natl Acad Sci U S A. 2016. PMID: 26802120 Free PMC article.
• Tertiary Plasticity Drives the Efficiency of Enterocin 7B Interactions with Lipid Membranes.
  Zhuang Y, Quirk S, Stover ER, Bureau HR, Allen CR, Hernandez R. Zhuang Y, et al. J Phys Chem B. 2024 Mar 7;128(9):2100-2113. doi: 10.1021/acs.jpcb.3c08199. Epub 2024 Feb 27. J Phys Chem B. 2024. PMID: 38412510 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.