Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma - PubMed (original) (raw)
Case Reports
Granulocyte-colony-stimulating-factor-producing hepatocellular carcinoma
S Yamamoto et al. J Gastroenterol. 1999 Oct.
Abstract
Patients with hepatocellular carcinoma (HCC) rarely show marked granulocytosis. We report an interesting case of rapidly growing poorly differentiated HCC associated with marked granulocytosis. The blood leukocyte count decreased following several treatments for HCC, including transcatheter arterial embolization, and increased again along with tumor regrowth. The serum levels of granulocyte colony-stimulating factor (G-CSF) were markedly elevated, and immunohistochemical study showed G-CSF staining in the cytoplasm of certain HCC cells. These findings confirm that HCC in this case was a G-CSF-producing tumor.
Similar articles
- Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case.
Kohno M, Shirabe K, Mano Y, Muto J, Motomura T, Takeishi K, Toshima T, Yoshimatsu M, Ijichi H, Harada N, Aishima S, Uchiyama H, Yoshizumi T, Taketomi A, Maehara Y. Kohno M, et al. Surg Today. 2013 Apr;43(4):439-45. doi: 10.1007/s00595-012-0202-0. Epub 2012 May 26. Surg Today. 2013. PMID: 22638568 - Hepatocellular carcinoma producing a granulocyte colony-stimulating factor: report of a resected case with a literature review.
Araki K, Kishihara F, Takahashi K, Matsumata T, Shimura T, Suehiro T, Kuwano H. Araki K, et al. Liver Int. 2007 Jun;27(5):716-21. doi: 10.1111/j.1478-3231.2007.01468.x. Liver Int. 2007. PMID: 17498259 Review. - A case of granulocyte-colony stimulating factor-producing hepatocellular carcinoma confirmed by immunohistochemistry.
Joshita S, Nakazawa K, Koike S, Kamijo A, Matsubayashi K, Miyabayashi H, Furuta K, Kitano K, Yoshizawa K, Tanaka E. Joshita S, et al. J Korean Med Sci. 2010 Mar;25(3):476-80. doi: 10.3346/jkms.2010.25.3.476. Epub 2010 Feb 17. J Korean Med Sci. 2010. PMID: 20191051 Free PMC article. - Carcinosarcoma of the liver producing granulocyte-colony stimulating factor.
Aita K, Seki K. Aita K, et al. Pathol Int. 2006 Jul;56(7):413-9. doi: 10.1111/j.1440-1827.2006.01979.x. Pathol Int. 2006. PMID: 16792552 - Granulocyte colony-stimulating factor-producing hepatocellular carcinoma with abrupt changes.
Nagata H, Komatsu S, Takaki W, Okayama T, Sawabe Y, Ishii M, Kishimoto M, Otsuji E, Konosu H. Nagata H, et al. World J Clin Oncol. 2016 Oct 10;7(5):380-386. doi: 10.5306/wjco.v7.i5.380. World J Clin Oncol. 2016. PMID: 27777880 Free PMC article. Review.
Cited by
- G-CSF promotes the development of hepatocellular carcinoma by activating the PI3K/AKT/mTOR pathway in TAM.
Cao H, Wang S. Cao H, et al. Aging (Albany NY). 2024 Jul 1;16(13):10799-10812. doi: 10.18632/aging.205922. Epub 2024 Jul 1. Aging (Albany NY). 2024. PMID: 38967628 Free PMC article. - Advances in Histological and Molecular Classification of Hepatocellular Carcinoma.
Choi JH, Thung SN. Choi JH, et al. Biomedicines. 2023 Sep 20;11(9):2582. doi: 10.3390/biomedicines11092582. Biomedicines. 2023. PMID: 37761023 Free PMC article. Review. - FasL+ PD-L2+ Identifies a Novel Immunosuppressive Neutrophil Population in Human Gastric Cancer That Promotes Disease Progression.
Shan ZG, Zhao YL, Zhang JY, Yan ZB, Wang TT, Mao FY, Teng YS, Peng LS, Chen WY, Wang P, Cheng P, Tian WQ, Chen J, Chen W, Zhuang Y. Shan ZG, et al. Adv Sci (Weinh). 2022 Feb;9(5):e2103543. doi: 10.1002/advs.202103543. Epub 2021 Dec 26. Adv Sci (Weinh). 2022. PMID: 34957697 Free PMC article. - Hepatocellular carcinoma: making sense of morphological heterogeneity, growth patterns, and subtypes.
Torbenson MS. Torbenson MS. Hum Pathol. 2021 Jun;112:86-101. doi: 10.1016/j.humpath.2020.12.009. Epub 2020 Dec 30. Hum Pathol. 2021. PMID: 33387587 Free PMC article. Review. - Structural Study of Monomethyl Fumarate-Bound Human GAPDH.
Park JB, Park H, Son J, Ha SJ, Cho HS. Park JB, et al. Mol Cells. 2019 Aug 31;42(8):597-603. doi: 10.14348/molcells.2019.0114. Mol Cells. 2019. PMID: 31387164 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical