Memory CD4 cells do not migrate into peripheral lymphnodes in the absence of antigen - PubMed (original) (raw)
Memory CD4 cells do not migrate into peripheral lymphnodes in the absence of antigen
L M Bradley et al. Eur J Immunol. 1999 Oct.
Free article
Abstract
Memory T cells are thought to protect against previously encountered pathogens in part by preferentially recirculating through the lymphoid tissues where they were primed and where challenge with antigen (Ag) is likely to occur. In this study, we examined the distribution of memory CD4 cells after priming, and analyzed their capacity to localize in lymph nodes after transfer to normal and Ag-primed recipients. Immunization induced a high frequency of Ag-specific CD4 cells in the primary response in draining lymph nodes and spleen. Thereafter, the numbers in lymph nodes declined dramatically whereas frequencies in the spleen were unchanged, suggesting that memory CD4 cells primarily reside in or recirculate through the spleen. Indeed, memory CD4 cells, unlike naive CD4 cells, failed to home to lymph nodes after adoptive transfer to normal recipients and were detected predominantly in the spleen for extended periods, suggesting that recirculation through lymph nodes was limited. Memory cells also did not home to lymph nodes recipients in response to specific Ag, but subsequently, recruitment that could be blocked with monoclonal antibodies to CD44 and LFA-1 and was independent of naive cells did occur. The data indicate that memory and naive CD4 cells can be distinguished on the basis of their patterns of circulation.
Similar articles
- Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor.
Bradley LM, Atkins GG, Swain SL. Bradley LM, et al. J Immunol. 1992 Jan 15;148(2):324-31. J Immunol. 1992. PMID: 1345918 - The migratory behavior of murine CD4+ cells of memory phenotype.
Tietz W, Hamann A. Tietz W, et al. Eur J Immunol. 1997 Sep;27(9):2225-32. doi: 10.1002/eji.1830270916. Eur J Immunol. 1997. PMID: 9341763 - Phenotype and homing of CD4 tumor-specific T cells is modulated by tumor bulk.
Benigni F, Zimmermann VS, Hugues S, Caserta S, Basso V, Rivino L, Ingulli E, Malherbe L, Glaichenhaus N, Mondino A. Benigni F, et al. J Immunol. 2005 Jul 15;175(2):739-48. doi: 10.4049/jimmunol.175.2.739. J Immunol. 2005. PMID: 16002669 - Migration pathways and immunologic memory among T lymphocytes.
Mackay CR. Mackay CR. Semin Immunol. 1992 Feb;4(1):51-8. Semin Immunol. 1992. PMID: 1534264 Review. - The effector to memory transition of CD4 T cells.
McKinstry KK, Strutt TM, Swain SL. McKinstry KK, et al. Immunol Res. 2008;40(2):114-27. doi: 10.1007/s12026-007-8004-y. Immunol Res. 2008. PMID: 18213525 Review.
Cited by
- Kruppel-like factor 2 is required for trafficking but not quiescence in postactivated T cells.
Takada K, Wang X, Hart GT, Odumade OA, Weinreich MA, Hogquist KA, Jameson SC. Takada K, et al. J Immunol. 2011 Jan 15;186(2):775-83. doi: 10.4049/jimmunol.1000094. Epub 2010 Dec 15. J Immunol. 2011. PMID: 21160050 Free PMC article. - The potential of CD4 T-cell memory.
McKinstry KK, Strutt TM, Swain SL. McKinstry KK, et al. Immunology. 2010 May;130(1):1-9. doi: 10.1111/j.1365-2567.2010.03259.x. Epub 2010 Mar 16. Immunology. 2010. PMID: 20331470 Free PMC article. Review. - Nasal delivery of antigen with the B subunit of Escherichia coli heat-labile enterotoxin augments antigen-specific T-cell clonal expansion and differentiation.
Apostolaki M, Williams NA. Apostolaki M, et al. Infect Immun. 2004 Jul;72(7):4072-80. doi: 10.1128/IAI.72.7.4072-4080.2004. Infect Immun. 2004. PMID: 15213152 Free PMC article. - Interleukin 7 regulates the survival and generation of memory CD4 cells.
Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. Kondrack RM, et al. J Exp Med. 2003 Dec 15;198(12):1797-806. doi: 10.1084/jem.20030735. Epub 2003 Dec 8. J Exp Med. 2003. PMID: 14662907 Free PMC article. - CCR4-bearing T cells participate in autoimmune diabetes.
Kim SH, Cleary MM, Fox HS, Chantry D, Sarvetnick N. Kim SH, et al. J Clin Invest. 2002 Dec;110(11):1675-86. doi: 10.1172/JCI15547. J Clin Invest. 2002. PMID: 12464673 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous