Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term - PubMed (original) (raw)
Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term
T E Inder et al. Ann Neurol. 1999 Nov.
Abstract
Periventricular white matter injury, that is, periventricular leukomalacia (PVL), the dominant form of brain injury in the premature infant, is the major neuropathological substrate associated with the motor and cognitive deficits observed later in such infants. The nature of the relationship of this lesion to the subsequent cognitive deficits is unclear, but such deficits raise the possibility of cerebral cortical neuronal dysfunction. Although cortical neuronal necrosis is not a prominent feature of brain injury in premature infants, the possibility of a deleterious effect of PVL on subsequent cerebral cortical development has not been investigated. An advanced quantitative volumetric three-dimensional magnetic resonance imaging technique was used to measure brain tissue volumes at term in premature infants with earlier ultrasonographic and magnetic resonance imaging evidence of PVL (mean gestational age at birth, 28.7 +/- 2.0 weeks; n = 10), in premature infants with normal imaging studies (mean gestational age at birth, 29.0 +/- 2.1 weeks; n = 10), and in control term infants (n = 14). Premature infants with PVL had a marked reduction in cerebral cortical gray matter at term compared with either premature infants without PVL or normal term infants (mean +/- SD: PVL, 157.5 +/- 41.5 ml; no PVL, 211.7 +/- 25.4 ml; normal term, 218.8 +/- 21.3 ml). As expected, a reduction in the volume of total brain myelinated white matter was also noted (mean +/- SD: PVL, 14.5 +/- 4.6 ml; no PVL, 23.1 +/- 6.9 ml; normal term, 27.6 +/- 10.3 ml). An apparent compensatory increase in total cerebrospinal fluid volume also was found (mean +/- SD: PVL, 64.5 +/- 15.2 ml; no PVL, 52.0 +/- 24.1 ml; normal term, 32.9 +/- 13.5 ml). PVL in the premature infant is shown for the first time to be followed by impaired cerebral cortical development. These findings may provide insight into the anatomical correlate for the intellectual deficits associated with PVL in the premature infant.
Similar articles
- Abnormal cerebral structure is present at term in premature infants.
Inder TE, Warfield SK, Wang H, Hüppi PS, Volpe JJ. Inder TE, et al. Pediatrics. 2005 Feb;115(2):286-94. doi: 10.1542/peds.2004-0326. Pediatrics. 2005. PMID: 15687434 - Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease.
Murphy BP, Inder TE, Huppi PS, Warfield S, Zientara GP, Kikinis R, Jolesz FA, Volpe JJ. Murphy BP, et al. Pediatrics. 2001 Feb;107(2):217-21. doi: 10.1542/peds.107.2.217. Pediatrics. 2001. PMID: 11158449 - Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?
Kadhim H, Tabarki B, De Prez C, Sébire G. Kadhim H, et al. Acta Neuropathol. 2003 Mar;105(3):209-16. doi: 10.1007/s00401-002-0633-6. Epub 2002 Nov 20. Acta Neuropathol. 2003. PMID: 12557006 - White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome.
Perlman JM. Perlman JM. Early Hum Dev. 1998 Dec;53(2):99-120. doi: 10.1016/s0378-3782(98)00037-1. Early Hum Dev. 1998. PMID: 10195704 Review. - The near-term (late preterm) human brain and risk for periventricular leukomalacia: a review.
Kinney HC. Kinney HC. Semin Perinatol. 2006 Apr;30(2):81-8. doi: 10.1053/j.semperi.2006.02.006. Semin Perinatol. 2006. PMID: 16731282 Review.
Cited by
- Magnetic resonance imaging of white matter diseases of prematurity.
Rutherford MA, Supramaniam V, Ederies A, Chew A, Bassi L, Groppo M, Anjari M, Counsell S, Ramenghi LA. Rutherford MA, et al. Neuroradiology. 2010 Jun;52(6):505-21. doi: 10.1007/s00234-010-0700-y. Epub 2010 Apr 27. Neuroradiology. 2010. PMID: 20422407 - Automatic extraction of the intracranial volume in fetal and neonatal MR scans using convolutional neural networks.
Khalili N, Turk E, Benders MJNL, Moeskops P, Claessens NHP, de Heus R, Franx A, Wagenaar N, Breur JMPJ, Viergever MA, Išgum I. Khalili N, et al. Neuroimage Clin. 2019;24:102061. doi: 10.1016/j.nicl.2019.102061. Epub 2019 Nov 9. Neuroimage Clin. 2019. PMID: 31835284 Free PMC article. - Functional connectivity to a right hemisphere language center in prematurely born adolescents.
Myers EH, Hampson M, Vohr B, Lacadie C, Frost SJ, Pugh KR, Katz KH, Schneider KC, Makuch RW, Constable RT, Ment LR. Myers EH, et al. Neuroimage. 2010 Jul 15;51(4):1445-52. doi: 10.1016/j.neuroimage.2010.03.049. Epub 2010 Mar 25. Neuroimage. 2010. PMID: 20347043 Free PMC article. - New concepts in perinatal hypoxia ischemia encephalopathy.
Scafidi J, Gallo V. Scafidi J, et al. Curr Neurol Neurosci Rep. 2008 Mar;8(2):130-8. doi: 10.1007/s11910-008-0021-2. Curr Neurol Neurosci Rep. 2008. PMID: 18460281 Review. - Executive Functioning and Learning Skills of Adolescent Children Born at Fewer than 26 Weeks of Gestation.
Farooqi A, Adamsson M, Serenius F, Hägglöf B. Farooqi A, et al. PLoS One. 2016 Mar 21;11(3):e0151819. doi: 10.1371/journal.pone.0151819. eCollection 2016. PLoS One. 2016. PMID: 26999522 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials