The nuclear pore complex protein Nup88 is overexpressed in tumor cells - PubMed (original) (raw)
. 1999 Nov 1;59(21):5408-11.
Affiliations
- PMID: 10554006
The nuclear pore complex protein Nup88 is overexpressed in tumor cells
N Martínez et al. Cancer Res. 1999.
Abstract
It has been previously shown (J. Schneider et al., Br. J. Cancer, 77: 1015-1020, 1998) that an antibody directed against Candida albicans proteins (C6) recognizes specifically a protein in human ovarian tumors. We have now performed an immunoscreening of a human cDNA library using this antibody and identified the antigen as Nup88, a protein localized preferentially at the nuclear membrane and probably implicated in nucleocytoplasmic transport. Our results show that Nup88 is strongly expressed in a series of human tumor cell lines compared with nontransformed cell lines at the RNA and the protein levels. Furthermore, we observed that in 76% of 21 ovarian tumors analyzed, the protein is also overexpressed in malignant tissue when compared with healthy adjacent tissue. Nup88 may, therefore, be considered as a putative marker for tumor growth and is probably related to increased cell cycling.
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