Thalamic single neuron activity in patients with dystonia: dystonia-related activity and somatic sensory reorganization - PubMed (original) (raw)
. 1999 Nov;82(5):2372-92.
doi: 10.1152/jn.1999.82.5.2372.
Affiliations
- PMID: 10561412
- DOI: 10.1152/jn.1999.82.5.2372
Free article
Thalamic single neuron activity in patients with dystonia: dystonia-related activity and somatic sensory reorganization
F A Lenz et al. J Neurophysiol. 1999 Nov.
Free article
Abstract
Indirect evidence suggests that the thalamus contributes to abnormal movements occurring in patients with dystonia (dystonia patients). The present study tested the hypothesis that thalamic activity contributes to the dystonic movements that occur in such patients. During these movements, spectral analysis of electromyographic (EMG) signals in flexor and extensor muscles of the wrist and elbow exhibited peak EMG power in the lowest frequency band [0-0.78 Hz (mean: 0.39 Hz) dystonia frequency] for 60-85% of epochs studied during a pointing task. Normal controls showed low-frequency peaks for <16% of epochs during pointing. Among dystonia patients, simultaneous contraction of antagonistic muscles (cocontraction) at dystonia frequency during pointing was observed for muscles acting about the wrist (63% of epochs) and elbow (39%), but cocontraction was not observed among normal controls during pointing. Thalamic neuronal signals were recorded during thalamotomy for treatment of dystonia and were compared with those of control patients without motor abnormality who were undergoing thalamic procedures for treatment of chronic pain. Presumed nuclear boundaries of a human thalamic cerebellar relay nucleus (ventral intermediate, Vim) and a pallidal relay nucleus (ventral oral posterior, Vop) were estimated by aligning the anterior border of the principal sensory nucleus (ventral caudal, Vc) with the region where the majority of cells have cutaneous receptive fields (RFs). The ratio of power at dystonia frequency to average spectral power was >2 (P < 0.001) for cells in presumed Vop often for dystonia patients (81%) but never for control patients. The percentage of such cells in presumed Vim of dystonia patients (32%) was not significantly different from that of controls (31%). Many cells in presumed Vop exhibited dystonia frequency activity that was correlated with and phase-advanced on EMG activity during dystonia, suggesting that this activity was related to dystonia. Thalamic somatic sensory activity also differed between dystonia patients and controls. The percentage of cells responding to passive joint movement or to manipulation of subcutaneous structures (deep sensory cells) in presumed Vim was significantly greater in patients with dystonia than in control patients undergoing surgery for treatment of pain or tremor. Dystonia patients had a significantly higher proportion of deep sensory cells responding to movement of more than one joint (26%, 13/52) than did "control" patients (8%, 4/49). Deep sensory cells in patients with dystonia were located in thalamic maps that demonstrated increased representations of parts of the body affected by dystonia. Thus dystonia patients showed increased receptive fields and an increased thalamic representation of dystonic body parts. The motor activity of an individual sensory cell was related to the sensory activity of that cell by identification of the muscle apparently involved in the cell's receptive field. Specifically, we defined the effector muscle as the muscle that, by contraction, produced the joint movement associated with a thalamic neuronal sensory discharge, when the examiner passively moved the joint. Spike X EMG correlation functions during dystonia indicated that thalamic cellular activity less often was related to EMG in effector muscles (52%) than in other muscles (86%). Thus there is a mismatch between the effector muscle for a thalamic cell and the muscles with EMG correlated with activity of that cell during dystonia. This mismatch may result from the reorganization of sensory maps and may contribute to the simultaneous activation of multiple muscles observed in dystonia. Microstimulation in presumed Vim in dystonia patients produced simultaneous contraction of multiple forearm muscles, similar to the simultaneous muscle contractions observed in dystonia. (ABSTRACT TRUNCATED)
Similar articles
- Single-neuron analysis of human thalamus in patients with intention tremor and other clinical signs of cerebellar disease.
Lenz FA, Jaeger CJ, Seike MS, Lin YC, Reich SG. Lenz FA, et al. J Neurophysiol. 2002 Apr;87(4):2084-94. doi: 10.1152/jn.00049.2001. J Neurophysiol. 2002. PMID: 11929926 - Neuronal activity in the basal ganglia and thalamus in patients with dystonia.
Zhuang P, Li Y, Hallett M. Zhuang P, et al. Clin Neurophysiol. 2004 Nov;115(11):2542-57. doi: 10.1016/j.clinph.2004.06.006. Clin Neurophysiol. 2004. PMID: 15465444 - Reorganization in the cutaneous core of the human thalamic principal somatic sensory nucleus (Ventral caudal) in patients with dystonia.
Lenz FA, Byl NN. Lenz FA, et al. J Neurophysiol. 1999 Dec;82(6):3204-12. doi: 10.1152/jn.1999.82.6.3204. J Neurophysiol. 1999. PMID: 10601454 Clinical Trial. - Neuronal responses to tactile stimuli and tactile sensations evoked by microstimulation in the human thalamic principal somatic sensory nucleus (ventral caudal).
Schmid AC, Chien JH, Greenspan JD, Garonzik I, Weiss N, Ohara S, Lenz FA. Schmid AC, et al. J Neurophysiol. 2016 Jun 1;115(5):2421-33. doi: 10.1152/jn.00611.2015. Epub 2016 Feb 10. J Neurophysiol. 2016. PMID: 26864759 Free PMC article. Review. - [A case of post-hemiplegic painful dystonia following thalamic infarction with good response to botulinus toxin].
Motoi Y, Hattori Y, Miwa H, Shina K, Mizuno Y. Motoi Y, et al. Rinsho Shinkeigaku. 1997 Oct;37(10):881-6. Rinsho Shinkeigaku. 1997. PMID: 9490897 Review. Japanese.
Cited by
- Thalamic structural connectivity profiles in blepharospam/Meige's syndrome.
Mantel T, Jochim A, Meindl T, Deppe J, Zimmer C, Li Y, Haslinger B. Mantel T, et al. Neuroimage Clin. 2022;34:103013. doi: 10.1016/j.nicl.2022.103013. Epub 2022 Apr 22. Neuroimage Clin. 2022. PMID: 35483134 Free PMC article. - Thalamic Deep Brain Stimulation Is Effective in Alleviating Craniocervical Dystonia.
Evidente VGH, Rokhlin P, Evidente MH, Lambert M, Garrett R, Ponce FA. Evidente VGH, et al. Mov Disord Clin Pract. 2021 May 24;8(5):778-781. doi: 10.1002/mdc3.13233. eCollection 2021 Jul. Mov Disord Clin Pract. 2021. PMID: 34307753 Free PMC article. No abstract available. - Adductor Spasmodic Dysphonia Improves with Bilateral Thalamic Deep Brain Stimulation: Report of 3 Cases Done Asleep and Review of Literature.
Evidente VGH, Ponce FA, Evidente MH, Lambert M, Garrett R, Sugumaran M, Lott DG. Evidente VGH, et al. Tremor Other Hyperkinet Mov (N Y). 2020 Dec 31;10:60. doi: 10.5334/tohm.575. Tremor Other Hyperkinet Mov (N Y). 2020. PMID: 33505767 Free PMC article. Review. - Neurophysiological insights in dystonia and its response to deep brain stimulation treatment.
Tisch S, Limousin P. Tisch S, et al. Exp Brain Res. 2020 Aug;238(7-8):1645-1657. doi: 10.1007/s00221-020-05833-8. Epub 2020 Jul 7. Exp Brain Res. 2020. PMID: 32638036 Free PMC article. Review. - Safety and long-term efficacy of ventro-oral thalamotomy for focal hand dystonia: A retrospective study of 171 patients.
Horisawa S, Ochiai T, Goto S, Nakajima T, Takeda N, Fukui A, Hanada T, Kawamata T, Taira T. Horisawa S, et al. Neurology. 2019 Jan 22;92(4):e371-e377. doi: 10.1212/WNL.0000000000006818. Epub 2018 Dec 26. Neurology. 2019. PMID: 30587520 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous