Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila - PubMed (original) (raw)
Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila
G Segal et al. Mol Microbiol. 1999 Nov.
Free article
Abstract
We describe here a Legionella pneumophila type IV secretion system that is distinct from the previously described icm/dot system. This type IV secretion system contains 11 genes (lvh ) homologous to genes of other type IV secretion systems, arranged in a similar manner. The lvh genes were found to be located on a DNA island with a GC content higher than the L. pneumophila chromosome. In contrast to the icm/dot system that was shown to be required for intracellular growth in HL-60-derived human macrophages and Acanthamoeba castellanii, the lvh system was found to be dispensable for intracellular growth in these two hosts. The lvh system was found to be partially required for RSF1010 conjugation, a process that was previously shown to be completely dependent on several icm/dot genes. However, results obtained from analysis of double mutants in the icm/dot genes and the lvh genes revealed that lvh genes can substitute for some components of the icm/dot system for RSF1010 conjugation, but not for intracellular growth. These results indicate that components of the icm/dot system and components of the lvh type IV secretion system are able to interact with one another.
Similar articles
- Environmental mimics and the Lvh type IVA secretion system contribute to virulence-related phenotypes of Legionella pneumophila.
Bandyopadhyay P, Liu S, Gabbai CB, Venitelli Z, Steinman HM. Bandyopadhyay P, et al. Infect Immun. 2007 Feb;75(2):723-35. doi: 10.1128/IAI.00956-06. Epub 2006 Nov 13. Infect Immun. 2007. PMID: 17101653 Free PMC article. - Functional similarities between the icm/dot pathogenesis systems of Coxiella burnetii and Legionella pneumophila.
Zusman T, Yerushalmi G, Segal G. Zusman T, et al. Infect Immun. 2003 Jul;71(7):3714-23. doi: 10.1128/IAI.71.7.3714-3723.2003. Infect Immun. 2003. PMID: 12819052 Free PMC article. - The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetii.
Segal G, Feldman M, Zusman T. Segal G, et al. FEMS Microbiol Rev. 2005 Jan;29(1):65-81. doi: 10.1016/j.femsre.2004.07.001. FEMS Microbiol Rev. 2005. PMID: 15652976 Review. - Cell biology of Legionella pneumophila.
Vogel JP, Isberg RR. Vogel JP, et al. Curr Opin Microbiol. 1999 Feb;2(1):30-4. doi: 10.1016/s1369-5274(99)80005-8. Curr Opin Microbiol. 1999. PMID: 10047559 Review.
Cited by
- Migration of Acanthamoeba through Legionella biofilms is regulated by the bacterial Lqs-LvbR network, effector proteins and the flagellum.
Hochstrasser R, Michaelis S, Brülisauer S, Sura T, Fan M, Maaß S, Becher D, Hilbi H. Hochstrasser R, et al. Environ Microbiol. 2022 Aug;24(8):3672-3692. doi: 10.1111/1462-2920.16008. Epub 2022 May 25. Environ Microbiol. 2022. PMID: 35415862 Free PMC article. - Coxiella burnetii and Related Tick Endosymbionts Evolved from Pathogenic Ancestors.
Brenner AE, Muñoz-Leal S, Sachan M, Labruna MB, Raghavan R. Brenner AE, et al. Genome Biol Evol. 2021 Jul 6;13(7):evab108. doi: 10.1093/gbe/evab108. Genome Biol Evol. 2021. PMID: 34009306 Free PMC article. - Distribution of Virulence Genes and Sequence-Based Types Among Legionella pneumophila Isolated From the Water Systems of a Tertiary Care Hospital in India.
Sreenath K, Chaudhry R, Vinayaraj EV, Dey AB, Kabra SK, Thakur B, Guleria R. Sreenath K, et al. Front Public Health. 2020 Nov 23;8:596463. doi: 10.3389/fpubh.2020.596463. eCollection 2020. Front Public Health. 2020. PMID: 33330340 Free PMC article. - Legionella pneumophila p45 element influences host cell entry and sensitivity to sodium.
Christensen LM, Sule P, Strain M, Cirillo JD. Christensen LM, et al. PLoS One. 2019 Jun 27;14(6):e0218941. doi: 10.1371/journal.pone.0218941. eCollection 2019. PLoS One. 2019. PMID: 31246988 Free PMC article. - Disulfide loop cleavage of Legionella pneumophila PlaA boosts lysophospholipase A activity.
Lang C, Hiller M, Flieger A. Lang C, et al. Sci Rep. 2017 Nov 24;7(1):16313. doi: 10.1038/s41598-017-12796-4. Sci Rep. 2017. PMID: 29176577 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous