Effect of developmental and ancestral high-altitude exposure on VO(2)peak of Andean and European/North American natives - PubMed (original) (raw)
Effect of developmental and ancestral high-altitude exposure on VO(2)peak of Andean and European/North American natives
T D Brutsaert et al. Am J Phys Anthropol. 1999 Dec.
Abstract
Peak oxygen consumption (VO(2)peak) was measured in 150 adult males (18-35 years old) in Bolivia, using a complete migrant study design to partition developmental from ancestral (genetic) effects of high-altitude (HA) exposure. High-altitude natives (HANs, Aymara/Quechua ancestry, n = 75) and low-altitude natives (LANs, European/North American ancestry, n = 75) were studied at high altitude (3,600-3,850 m) and near sea level (420 m). HAN and LAN migrant groups to a nonnative environment were classified as: multigeneration migrants, born and raised in a nonnative environment; child migrants who migrated to the nonnative environment during the period of growth and development (0-18 years old); and adult migrants who migrated after 18 years of age. Variability in VO(2)peak due to high-altitude adaptation was modeled by covariance analysis, adjusting for fat-free mass and physical activity (training) differences between groups. A trend for increased VO(2)peak with increasing developmental high-altitude exposure in migrant groups did not reach statistical significance, but low statistical power may have limited the ability to detect this effect. HANs and LANs born, raised, and tested at high altitude had similar VO(2)peak values, indicating no genetic effect, or an effect much smaller than that reported previously in the literature. There was no functional correlation between forced vital capacity and VO(2)peak, within or across groups. These results do not support the hypothesis that Andean HANs have been selected to express a greater physical work capacity in hypoxia.
Copyright 1999 Wiley-Liss, Inc.
Similar articles
- Effect of developmental and ancestral high altitude exposure on chest morphology and pulmonary function in Andean and European/North American natives.
Brutsaert TD, Soria R, Caceres E, Spielvogel H, Haas JD. Brutsaert TD, et al. Am J Hum Biol. 1999;11(3):383-395. doi: 10.1002/(SICI)1520-6300(1999)11:3<383::AID-AJHB9>3.0.CO;2-X. Am J Hum Biol. 1999. PMID: 11533958 - Higher arterial oxygen saturation during submaximal exercise in Bolivian Aymara compared to European sojourners and Europeans born and raised at high altitude.
Brutsaert TD, Araoz M, Soria R, Spielvogel H, Haas JD. Brutsaert TD, et al. Am J Phys Anthropol. 2000 Oct;113(2):169-81. doi: 10.1002/1096-8644(200010)113:2<169::AID-AJPA3>3.0.CO;2-9. Am J Phys Anthropol. 2000. PMID: 11002203 - Developmental, genetic, and environmental components of aerobic capacity at high altitude.
Frisancho AR, Frisancho HG, Milotich M, Brutsaert T, Albalak R, Spielvogel H, Villena M, Vargas E, Soria R. Frisancho AR, et al. Am J Phys Anthropol. 1995 Apr;96(4):431-42. doi: 10.1002/ajpa.1330960408. Am J Phys Anthropol. 1995. PMID: 7604895 - Population genetic aspects and phenotypic plasticity of ventilatory responses in high altitude natives.
Brutsaert TD. Brutsaert TD. Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):151-60. doi: 10.1016/j.resp.2007.03.004. Epub 2007 Mar 12. Respir Physiol Neurobiol. 2007. PMID: 17400521 Review. - Perspectives on functional adaptation of the high altitude native.
Frisancho AR. Frisancho AR. Prog Clin Biol Res. 1983;136:383-407. Prog Clin Biol Res. 1983. PMID: 6364176 Review.
Cited by
- Two routes to functional adaptation: Tibetan and Andean high-altitude natives.
Beall CM. Beall CM. Proc Natl Acad Sci U S A. 2007 May 15;104 Suppl 1(Suppl 1):8655-60. doi: 10.1073/pnas.0701985104. Epub 2007 May 9. Proc Natl Acad Sci U S A. 2007. PMID: 17494744 Free PMC article. - Relationship of pulmonary function among women and children to indoor air pollution from biomass use in rural Ecuador.
Rinne ST, Rodas EJ, Bender BS, Rinne ML, Simpson JM, Galer-Unti R, Glickman LT. Rinne ST, et al. Respir Med. 2006 Jul;100(7):1208-15. doi: 10.1016/j.rmed.2005.10.020. Epub 2005 Nov 28. Respir Med. 2006. PMID: 16318916 Free PMC article. - A cross-sectional study of differences in 6-min walk distance in healthy adults residing at high altitude versus sea level.
Caffrey D, Miranda JJ, Gilman RH, Davila-Roman VG, Cabrera L, Dowling R, Stewart T, Bernabe-Ortiz A, Wise R, Leon-Velarde F, Checkley W; CRONICAS Cohort Study Group. Caffrey D, et al. Extrem Physiol Med. 2014 Feb 1;3(1):3. doi: 10.1186/2046-7648-3-3. Extrem Physiol Med. 2014. PMID: 24484777 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources