FYVE-finger proteins--effectors of an inositol lipid - PubMed (original) (raw)
Review
. 1999 Dec:112 ( Pt 23):4175-83.
doi: 10.1242/jcs.112.23.4175.
Affiliations
- PMID: 10564636
- DOI: 10.1242/jcs.112.23.4175
Review
FYVE-finger proteins--effectors of an inositol lipid
H Stenmark et al. J Cell Sci. 1999 Dec.
Abstract
The binding of cytosolic proteins to specific intracellular membranes containing phosphorylated derivatives of phosphatidylinositol (PtdIns) is a common theme in vital cellular processes, such as cytoskeletal function, receptor signalling and membrane trafficking. Recently, several potential effectors of the phosphoinositide 3-kinase product PtdIns 3-phosphate (PtdIns(3)P) have emerged through the observation that a conserved zinc-finger-like domain, the FYVE-finger, binds specifically to this lipid. Here we review current knowledge about the structural basis for the FYVE-PtdIns(3)P interaction, its role in membrane recruitment of proteins and the functions of FYVE-finger proteins in membrane trafficking and other cellular processes.
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