Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain - PubMed (original) (raw)
Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
F Alliot et al. Brain Res Dev Brain Res. 1999.
Abstract
Microglia, the resident CNS macrophages, represent about 10% of the adult brain cell population. Although described a long time ago, their origin and developmental lineage is still debated. While del Rio-Hortega suggested that microglia originate from meningeal macrophages penetrating the brain during embryonic development, many authors claim that brain parenchymal microglia derive from circulating blood monocytes originating from bone marrow. We have previously reported that the late embryonic and adult mouse brain parenchyma contains potential microglial progenitors [F. Alliot, E. Lecain, B. Grima, B. Pessac, Microglial progenitors with a high proliferative capacity in the embryonic and the adult mouse brain, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 1541-1545]. We now report that they can be detected in the brain rudiment from embryonic day 8, after their appearance in the yolk sac and that their number increases until late gestation. We also show that microglia appear during embryonic development and that their number increases steadily during the first two postnatal weeks, when about 95% of microglia are born. Finally, the main finding of this study is that microglia is the result of in situ proliferation, as shown by the high proportion of parenchymal microglial cells that express PCNA, a marker of cell multiplication, in embryonic and postnatal brain. Taken together, our data support the hypothesis that terminally differentiated brain parenchymal microglia are derived from cells originating from the yolk sac whose progeny actively proliferates in situ during development.
Similar articles
- [Microglia: origin and development].
Pessac B, Godin I, Alliot F. Pessac B, et al. Bull Acad Natl Med. 2001;185(2):337-46; discussion 346-7. Bull Acad Natl Med. 2001. PMID: 11474589 French. - Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.
Gomez Perdiguero E, Klapproth K, Schulz C, Busch K, Azzoni E, Crozet L, Garner H, Trouillet C, de Bruijn MF, Geissmann F, Rodewald HR. Gomez Perdiguero E, et al. Nature. 2015 Feb 26;518(7540):547-51. doi: 10.1038/nature13989. Epub 2014 Dec 3. Nature. 2015. PMID: 25470051 Free PMC article. - [Microglia arise from extra-embryonic yolk sac primitive progenitors].
Ginhoux F, Merad M. Ginhoux F, et al. Med Sci (Paris). 2011 Aug-Sep;27(8-9):719-24. doi: 10.1051/medsci/2011278013. Epub 2011 Aug 31. Med Sci (Paris). 2011. PMID: 21880259 Review. French. - Fate mapping analysis reveals that adult microglia derive from primitive macrophages.
Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M. Ginhoux F, et al. Science. 2010 Nov 5;330(6005):841-5. doi: 10.1126/science.1194637. Epub 2010 Oct 21. Science. 2010. PMID: 20966214 Free PMC article. - Origin of microglia.
Kaur C, Hao AJ, Wu CH, Ling EA. Kaur C, et al. Microsc Res Tech. 2001 Jul 1;54(1):2-9. doi: 10.1002/jemt.1114. Microsc Res Tech. 2001. PMID: 11526953 Review.
Cited by
- From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy.
Dora D, Szőcs E, Soós Á, Halasy V, Somodi C, Mihucz A, Rostás M, Mógor F, Lohinai Z, Nagy N. Dora D, et al. Front Immunol. 2024 Sep 5;15:1434804. doi: 10.3389/fimmu.2024.1434804. eCollection 2024. Front Immunol. 2024. PMID: 39301033 Free PMC article. Review. - Role of Noncoding RNAs in Modulating Microglial Phenotype.
Meer E. Meer E. Glob Med Genet. 2024 Sep 9;11(4):304-311. doi: 10.1055/s-0044-1790283. eCollection 2024 Dec. Glob Med Genet. 2024. PMID: 39258255 Free PMC article. Review. - Microglia Colonization Associated with Angiogenesis and Neural Cell Development.
Harry GJ. Harry GJ. Adv Neurobiol. 2024;37:163-178. doi: 10.1007/978-3-031-55529-9_10. Adv Neurobiol. 2024. PMID: 39207692 Review. - Visualization, Fate Mapping, Ablation, and Mutagenesis of Microglia in the Mouse Brain.
Kim JS, Jung S. Kim JS, et al. Adv Neurobiol. 2024;37:53-63. doi: 10.1007/978-3-031-55529-9_4. Adv Neurobiol. 2024. PMID: 39207686 - History of Microglia.
Rezaie P, Hanisch UK. Rezaie P, et al. Adv Neurobiol. 2024;37:15-37. doi: 10.1007/978-3-031-55529-9_2. Adv Neurobiol. 2024. PMID: 39207684
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous