Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway - PubMed (original) (raw)
Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway
M T Puglielli et al. Nat Med. 1999 Dec.
Abstract
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
Similar articles
- Lymphotoxin-beta receptor immune interaction promotes tumor growth by inducing angiogenesis.
Hehlgans T, Stoelcker B, Stopfer P, Müller P, Cernaianu G, Guba M, Steinbauer M, Nedospasov SA, Pfeffer K, Männel DN. Hehlgans T, et al. Cancer Res. 2002 Jul 15;62(14):4034-40. Cancer Res. 2002. PMID: 12124338 - Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation--opposite functions for surface lymphotoxin expressed by T and B lymphocytes.
Jungbeck M, Stopfer P, Bataille F, Nedospasov SA, Männel DN, Hehlgans T. Jungbeck M, et al. Mol Immunol. 2008 Jan;45(1):34-41. doi: 10.1016/j.molimm.2007.05.007. Epub 2007 Jun 27. Mol Immunol. 2008. PMID: 17590442 - Attenuation of graft arterial disease by manipulation of the LIGHT pathway.
Kosuge H, Suzuki J, Kakuta T, Haraguchi G, Koga N, Futamatsu H, Gotoh R, Inobe M, Isobe M, Uede T. Kosuge H, et al. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1409-15. doi: 10.1161/01.ATV.0000134645.53285.02. Epub 2004 Jun 3. Arterioscler Thromb Vasc Biol. 2004. PMID: 15178556 - Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.
Liu W, Szalai A, Zhao L, Liu D, Martin F, Kimberly RP, Zhou T, Carter RH. Liu W, et al. Arthritis Rheum. 2004 Jun;50(6):1884-96. doi: 10.1002/art.20290. Arthritis Rheum. 2004. PMID: 15188365 - Monoclonal antibodies in the treatment of endotoxin shock (a review).
Sinkovics JG. Sinkovics JG. Acta Microbiol Hung. 1990;37(3):247-61. Acta Microbiol Hung. 1990. PMID: 2100899 Review. No abstract available.
Cited by
- Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.
Schnell FJ, Sundholm S, Crumley S, Iversen PL, Mourich DV. Schnell FJ, et al. PLoS Pathog. 2012 Dec;8(12):e1003073. doi: 10.1371/journal.ppat.1003073. Epub 2012 Dec 27. PLoS Pathog. 2012. PMID: 23300439 Free PMC article. - Lymphotoxin in physiology of lymphoid tissues - Implication for antiviral defense.
Koroleva EP, Fu YX, Tumanov AV. Koroleva EP, et al. Cytokine. 2018 Jan;101:39-47. doi: 10.1016/j.cyto.2016.08.018. Epub 2016 Sep 9. Cytokine. 2018. PMID: 27623349 Free PMC article. Review. - Effective Treatment of Experimental Lymphocytic Choriomeningitis Virus Infection: Consideration of Favipiravir for Use With Infected Organ Transplant Recipients.
Hickerson BT, Westover JB, Jung KH, Komeno T, Furuta Y, Gowen BB. Hickerson BT, et al. J Infect Dis. 2018 Jul 13;218(4):522-527. doi: 10.1093/infdis/jiy159. J Infect Dis. 2018. PMID: 29762684 Free PMC article. - Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses.
Tibbs TN, Donoghue LJ, Buzzelli AA, Misumi I, DeMonia M, Ferris MT, Kelada SNP, Whitmire JK. Tibbs TN, et al. iScience. 2023 Oct 28;26(11):108348. doi: 10.1016/j.isci.2023.108348. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026197 Free PMC article. - A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.
Gommerman JL, Giza K, Perper S, Sizing I, Ngam-Ek A, Nickerson-Nutter C, Browning JL. Gommerman JL, et al. J Clin Invest. 2003 Sep;112(5):755-67. doi: 10.1172/JCI18648. J Clin Invest. 2003. PMID: 12952924 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous