Pleiotropic cell-division defects and apoptosis induced by interference with survivin function - PubMed (original) (raw)

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

F Li et al. Nat Cell Biol. 1999 Dec.

Abstract

Here we investigate the role of the control of apoptosis in normal cell division. We show that interference with the expression or function of the apoptosis inhibitor survivin causes caspase-dependent cell death in the G2/M phase of the cell cycle, and a cell-division defect characterized by centrosome dysregulation, multipolar mitotic spindles and multinucleated, polyploid cells. Use of a dominant-negative survivin mutant or antisense survivin complementary DNA disrupts a supramolecular assembly of survivin, caspase-3 and the cyclin-dependent-kinase inhibitor p21Waf1/Cip1 within centrosomes, and results in caspase-dependent cleavage of p21. Polyploidy induced by survivin antagonists is accentuated in p21-deficient cells, and corrected by exogenous expression of p21. These findings show that control of apoptosis and preservation of p21 integrity within centrosomes by survivin are required for normal mitotic progression.

PubMed Disclaimer

Comment in

Survivin' cell-separation anxiety.
Reed JC, Reed SI. Reed JC, et al. Nat Cell Biol. 1999 Dec;1(8):E199-200. doi: 10.1038/70227. Nat Cell Biol. 1999. PMID: 10587656 No abstract available.

Cited by

Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase.
Asuncion Valenzuela MM, Castro I, Gonda A, Diaz Osterman CJ, Jutzy JM, Aspe JR, Khan S, Neidigh JW, Wall NR. Asuncion Valenzuela MM, et al. Onco Targets Ther. 2015 Feb 26;8:495-507. doi: 10.2147/OTT.S79647. eCollection 2015. Onco Targets Ther. 2015. PMID: 25767396 Free PMC article.
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
Okada H, Bakal C, Shahinian A, Elia A, Wakeham A, Suh WK, Duncan GS, Ciofani M, Rottapel R, Zúñiga-Pflücker JC, Mak TW. Okada H, et al. J Exp Med. 2004 Feb 2;199(3):399-410. doi: 10.1084/jem.20032092. J Exp Med. 2004. PMID: 14757745 Free PMC article.
Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia.
Liu X, Ryland L, Yang J, Liao A, Aliaga C, Watts R, Tan SF, Kaiser J, Shanmugavelandy SS, Rogers A, Loughran K, Petersen B, Yuen J, Meng F, Baab KT, Jarbadan NR, Broeg K, Zhang R, Liao J, Sayers TJ, Kester M, Loughran TP Jr. Liu X, et al. Blood. 2010 Nov 18;116(20):4192-201. doi: 10.1182/blood-2010-02-271080. Epub 2010 Jul 29. Blood. 2010. PMID: 20671121 Free PMC article.
The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney.
Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, Klanke B, Weidemann A, Warnecke C, Amann K, Engehausen D, Willam C, Eckardt KU, Rödel F, Wiesener MS. Lechler P, et al. Am J Pathol. 2007 Nov;171(5):1483-98. doi: 10.2353/ajpath.2007.070132. Am J Pathol. 2007. PMID: 17982126 Free PMC article.
M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis.
Abaza A, Soleilhac JM, Westendorf J, Piel M, Crevel I, Roux A, Pirollet F. Abaza A, et al. J Biol Chem. 2003 Jul 25;278(30):27844-52. doi: 10.1074/jbc.M304522200. Epub 2003 May 11. J Biol Chem. 2003. PMID: 12740395 Free PMC article.

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function - PubMed (original) (raw)