Stitching together RNA tertiary architectures - PubMed (original) (raw)

Review

. 1999 Dec 10;294(4):829-49.

doi: 10.1006/jmbi.1999.3312.

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Review

Stitching together RNA tertiary architectures

T Hermann et al. J Mol Biol. 1999.

Abstract

The powerful explanatory paradigm of molecular biology requiring form to co-evolve with function has again been proven successful when, over the recent two decades, a wealth of biological functions have been uncovered for RNA. Previously considered as a mere mediator of the genetic code, RNA is now acknowledged as a key player in a wide variety of cellular processes. Along with the discovery of novel biological functions of RNA molecules, a number of RNA three-dimensional structures have been solved which beautifully demonstrate the molecular adaptability which allows RNA to participate as a key player in these functions. A distinct repertoire of molecular motifs provides a basis for the assembly of complex RNA tertiary architectures.

Copyright 1999 Academic Press.

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