Human foamy virus genome in the thymus of myasthenia gravis patients - PubMed (original) (raw)
Affiliations
- PMID: 10592798
Human foamy virus genome in the thymus of myasthenia gravis patients
W T Liu et al. Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1996 Aug.
Abstract
The etiological relationship of human foamy virus (HFV), which is a spumaretrovirus, with human diseases is not clear. We analyzed thymus specimens from four patients with myasthenia gravis for the presence of HFV proviral genome by polymerase chain reaction (PCR). The results showed the presence of both 257 base pair (bp) and 299 bp DNA fragments representing a part of gag and bel-2 sequences, respectively, in all four thymuses. Their specificity was confirmed by Southern blot hybridization with the corresponding probes. This was also confirmed by sequence analysis, although there were some point mutations. We confirmed the presence of gag related sequence, a 1353 bp Xba I-cleaved DNA fragment in all four thymus samples, a 693 bp fragment in two (#3 and #4) and a 4300 bp Hind III-cleaved DNA fragment in another two (#1 and #4), indicating possible chromosomal integration of the HFV partial genome. To our knowledge, this is the first report on the presence of HFV genome in thymus tissues of myasthenia gravis patients. Our efforts to isolate the infectious HFV by cultivation of the tissues were not successful. Low titers of neutralizing antibody were detected in all four patients' serum samples. The possible role of the HFV in this autoimmune disease needs further investigation.
Similar articles
- Prevalence of human foamy virus-related sequences in the Korean population.
Lee H, Kim S, Kang M, Kim W, Cho B. Lee H, et al. J Biomed Sci. 1998 Jul-Aug;5(4):267-73. doi: 10.1007/BF02255858. J Biomed Sci. 1998. PMID: 9691219 - Isolation, cloning, and sequencing of simian foamy viruses from chimpanzees (SFVcpz): high homology to human foamy virus (HFV).
Herchenröder O, Renne R, Loncar D, Cobb EK, Murthy KK, Schneider J, Mergia A, Luciw PA. Herchenröder O, et al. Virology. 1994 Jun;201(2):187-99. doi: 10.1006/viro.1994.1285. Virology. 1994. PMID: 8184531 - Myasthenia gravis accompanied by thymomas not related to foamy virus genome in Belarusian's patients.
Kuzmenok OI, Dvoryanchikov GA, Ponomareva EN, Goncharov AA, Fomin IK, Lee ST, Sanberg PR, Potapnev MP. Kuzmenok OI, et al. Int J Neurosci. 2007 Nov;117(11):1603-10. doi: 10.1080/00207450701239442. Int J Neurosci. 2007. PMID: 17917929 - Human foamy virus: an underestimated neuropathogen?
Aguzzi A, Bothe K, Wagner EF, Rethwilm A, Horak I. Aguzzi A, et al. Brain Pathol. 1992 Jan;2(1):61-9. Brain Pathol. 1992. PMID: 1341948 Review. - [Neurotoxicity of human foamy virus in transgenic mice].
Aguzzi A. Aguzzi A. Verh Dtsch Ges Pathol. 1994;78:180-8. Verh Dtsch Ges Pathol. 1994. PMID: 7533983 Review. German.
Cited by
- Historical perspective of foamy virus epidemiology and infection.
Meiering CD, Linial ML. Meiering CD, et al. Clin Microbiol Rev. 2001 Jan;14(1):165-76. doi: 10.1128/CMR.14.1.165-176.2001. Clin Microbiol Rev. 2001. PMID: 11148008 Free PMC article. Review. - Absence of human T-cell lymphotropic virus type I and human foamy virus in thymoma.
Li H, Loehrer PJ Sr, Hisada M, Henley J, Whitby D, Engels EA. Li H, et al. Br J Cancer. 2004 Jun 1;90(11):2181-5. doi: 10.1038/sj.bjc.6601841. Br J Cancer. 2004. PMID: 15150553 Free PMC article. - Epidemiology of thymoma and associated malignancies.
Engels EA. Engels EA. J Thorac Oncol. 2010 Oct;5(10 Suppl 4):S260-5. doi: 10.1097/JTO.0b013e3181f1f62d. J Thorac Oncol. 2010. PMID: 20859116 Free PMC article. Review. - Is there any relationship between human foamy virus infections and familial Mediterranean fever?
Yüce M, Bagci H, Cengiz K. Yüce M, et al. J Res Med Sci. 2018 Sep 24;23:78. doi: 10.4103/jrms.JRMS_1001_16. eCollection 2018. J Res Med Sci. 2018. PMID: 30294346 Free PMC article. - Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases.
Sun KH, Lin HY, Chen LW, Tai HY, Lin ML, Feng CK, Sung JS, Liu HF, Liu WT. Sun KH, et al. Clin Rheumatol. 2006 Sep;25(5):694-9. doi: 10.1007/s10067-005-0146-5. Epub 2005 Dec 20. Clin Rheumatol. 2006. PMID: 16365688
MeSH terms
LinkOut - more resources
Medical