ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors - PubMed (original) (raw)

ERK plays a regulatory role in induction of LTP by theta frequency stimulation and its modulation by beta-adrenergic receptors

D G Winder et al. Neuron. 1999 Nov.

Free article

Abstract

MAP kinase (ERK) translates cell surface signals into alterations in transcription. We have found that ERK also regulates hippocampal neuronal excitability during 5 Hz stimulation and thereby regulates forms of long-term potentiation (LTP) that do not require macromolecular synthesis. Moreover, ERK-mediated changes in excitability are selectively required for some forms of LTP but not others. ERK is required for the early phase of LTP elicited by brief 5 Hz stimulation, as well as for LTP elicited by more prolonged 5 Hz stimulation when paired with beta1-adrenergic receptor activation. By contrast, ERK plays no role in LTP elicited by a single 1 s 100 Hz train. Consistent with these results, we find that ERK is activated by beta-adrenergic receptors in CA1 pyramidal cell somas and dendrites.

PubMed Disclaimer

Similar articles

• Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation.
  Giovannini MG, Blitzer RD, Wong T, Asoma K, Tsokas P, Morrison JH, Iyengar R, Landau EM. Giovannini MG, et al. J Neurosci. 2001 Sep 15;21(18):7053-62. doi: 10.1523/JNEUROSCI.21-18-07053.2001. J Neurosci. 2001. PMID: 11549715 Free PMC article.
• Beta-adrenergic receptor activation facilitates induction of a protein synthesis-dependent late phase of long-term potentiation.
  Gelinas JN, Nguyen PV. Gelinas JN, et al. J Neurosci. 2005 Mar 30;25(13):3294-303. doi: 10.1523/JNEUROSCI.4175-04.2005. J Neurosci. 2005. PMID: 15800184 Free PMC article.
• Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.
  Nguyen PV, Duffy SN, Young JZ. Nguyen PV, et al. J Neurophysiol. 2000 Nov;84(5):2484-93. doi: 10.1152/jn.2000.84.5.2484. J Neurophysiol. 2000. PMID: 11067991
• 5-Hz stimulation of CA3 pyramidal cell axons induces a beta-adrenergic modulated potentiation at synapses on CA1, but not CA3, pyramidal cells.
  Moody TD, Thomas MJ, Makhinson M, O'Dell TJ. Moody TD, et al. Brain Res. 1998 May 25;794(1):75-9. doi: 10.1016/s0006-8993(98)00217-0. Brain Res. 1998. PMID: 9630529

Cited by

• The role of extracellular regulated kinases I/II in late-phase long-term potentiation.
  Rosenblum K, Futter M, Voss K, Erent M, Skehel PA, French P, Obosi L, Jones MW, Bliss TV. Rosenblum K, et al. J Neurosci. 2002 Jul 1;22(13):5432-41. doi: 10.1523/JNEUROSCI.22-13-05432.2002. J Neurosci. 2002. PMID: 12097495 Free PMC article.
• Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
  Zhuang ZY, Xu H, Clapham DE, Ji RR. Zhuang ZY, et al. J Neurosci. 2004 Sep 22;24(38):8300-9. doi: 10.1523/JNEUROSCI.2893-04.2004. J Neurosci. 2004. PMID: 15385613 Free PMC article.
• Calcium release from presynaptic ryanodine-sensitive stores is required for long-term depression at hippocampal CA3-CA3 pyramidal neuron synapses.
  Unni VK, Zakharenko SS, Zablow L, DeCostanzo AJ, Siegelbaum SA. Unni VK, et al. J Neurosci. 2004 Oct 27;24(43):9612-22. doi: 10.1523/JNEUROSCI.5583-03.2004. J Neurosci. 2004. PMID: 15509748 Free PMC article.
• Phosphorylation changes of CaMKII, ERK1/2, PKB/Akt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses.
  Racaniello M, Cardinale A, Mollinari C, D'Antuono M, De Chiara G, Tancredi V, Merlo D. Racaniello M, et al. Neurochem Res. 2010 Feb;35(2):239-46. doi: 10.1007/s11064-009-0047-0. Neurochem Res. 2010. PMID: 19731018
• Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway.
  Wu GY, Deisseroth K, Tsien RW. Wu GY, et al. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2808-13. doi: 10.1073/pnas.051634198. Epub 2001 Feb 20. Proc Natl Acad Sci U S A. 2001. PMID: 11226322 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal