Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase - PubMed (original) (raw)
Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase
C Cogoni et al. Science. 1999.
Abstract
The phenomenon of posttranscriptional gene silencing (PTGS), which occurs when a transgene is introduced into a cell, is poorly understood. Here, the qde-3 gene, which is required for the activation and maintenance of gene silencing in the fungus Neurospora crassa, was isolated. Sequence analysis revealed that the qde-3 gene belongs to the RecQ DNA helicase family. The QDE3 protein may function in the DNA-DNA interaction between introduced transgenes or with an endogenous gene required for gene-silencing activation. In animals, genes that are homologous to RecQ protein, such as the human genes for Bloom's syndrome and Werner's syndrome, may also function in PTGS.
Similar articles
- The QDE-3 homologue RecQ-2 co-operates with QDE-3 in DNA repair in Neurospora crassa.
Pickford A, Braccini L, Macino G, Cogoni C. Pickford A, et al. Curr Genet. 2003 Jan;42(4):220-7. doi: 10.1007/s00294-002-0351-6. Epub 2002 Dec 10. Curr Genet. 2003. PMID: 12589473 - Sit down, relax and unwind: structural insights into RecQ helicase mechanisms.
Killoran MP, Keck JL. Killoran MP, et al. Nucleic Acids Res. 2006;34(15):4098-105. doi: 10.1093/nar/gkl538. Epub 2006 Aug 25. Nucleic Acids Res. 2006. PMID: 16935877 Free PMC article. Review. - The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair.
Kato A, Akamatsu Y, Sakuraba Y, Inoue H. Kato A, et al. Curr Genet. 2004 Feb;45(1):37-44. doi: 10.1007/s00294-003-0459-3. Epub 2003 Nov 1. Curr Genet. 2004. PMID: 14595518 - Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
Furuichi Y. Furuichi Y. Ann N Y Acad Sci. 2001 Apr;928:121-31. doi: 10.1111/j.1749-6632.2001.tb05642.x. Ann N Y Acad Sci. 2001. PMID: 11795503 Review.
Cited by
- Challenges and Opportunities Arising from Host-Botrytis cinerea Interactions to Outline Novel and Sustainable Control Strategies: The Key Role of RNA Interference.
Spada M, Pugliesi C, Fambrini M, Pecchia S. Spada M, et al. Int J Mol Sci. 2024 Jun 20;25(12):6798. doi: 10.3390/ijms25126798. Int J Mol Sci. 2024. PMID: 38928507 Free PMC article. Review. - Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1.
Cui R, Li H, Zhao J, Li X, Gan J, Ma J. Cui R, et al. Nucleic Acids Res. 2022 Sep 23;50(17):10169-10186. doi: 10.1093/nar/gkac727. Nucleic Acids Res. 2022. PMID: 36039765 Free PMC article. - Transcriptional regulation by a RecQ helicase.
Debnath S, Lu X, Sharma S. Debnath S, et al. Methods Enzymol. 2022;673:227-249. doi: 10.1016/bs.mie.2022.03.057. Epub 2022 Apr 18. Methods Enzymol. 2022. PMID: 35965009 Free PMC article. - Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.
Lu X, Redon CE, Tang W, Parvathaneni S, Bokhari B, Debnath S, Li XL, Muys BR, Song Y, Pongor LS, Sheikh O, Green AR, Madhusudan S, Lal A, Ambs S, Khan J, Aladjem MI, Sharma S. Lu X, et al. Mol Cell Biol. 2021 Mar 24;41(4):e00515-20. doi: 10.1128/MCB.00515-20. Print 2021 Mar 24. Mol Cell Biol. 2021. PMID: 33468559 Free PMC article. - Establishment of Neurospora crassa as a model organism for fungal virology.
Honda S, Eusebio-Cope A, Miyashita S, Yokoyama A, Aulia A, Shahi S, Kondo H, Suzuki N. Honda S, et al. Nat Commun. 2020 Nov 6;11(1):5627. doi: 10.1038/s41467-020-19355-y. Nat Commun. 2020. PMID: 33159072 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources