Symposium: Cognitive processes and sleep disturbances: Sleep/wake patterns in Alzheimer's disease: relationships with cognition and function - PubMed (original) (raw)

Symposium: Cognitive processes and sleep disturbances: Sleep/wake patterns in Alzheimer's disease: relationships with cognition and function

KE Moe et al. J Sleep Res. 1995 Mar.

Abstract

Alzheimer's disease (AD), the most common dementing disorder of aging, is a progressive neurodegenerative disease of unknown etiology. Two of the common clinical features of AD are progressive cognitive and functional impairment, and disturbed sleep/wake patterns. We examined sleep/wake patterns and cognitive and functional status measures in a large sample of AD subjects ranging from mild to moderate-severe in impairment. All subjects survived at least 2 years after initial diagnosis. Regression analyses revealed that sleep/wake variables were highly correlated with and explained significant variance in cognitive and functional measures. More wakefulness during the night and longer REM latencies were associated with impaired cognition and function while more REM and slow-wave sleep were associated with preserved cognition and function. These results indicate that with advancing severity of the disease, sleep/wake patterns are disrupted in parallel with the disturbances in cognition and function that are the hallmarks of AD. Further, they suggest that the neural substrates underlying each process degenerate at somewhat comparable rates.

PubMed Disclaimer

Similar articles

• [Selective stimulations and lesions of the rat brain nuclei as the models for research of the human sleep pathology mechanisms].
  Šaponjić J. Šaponjić J. Glas Srp Akad Nauka Med. 2011;(51):85-97. Glas Srp Akad Nauka Med. 2011. PMID: 22165729 Review. Serbian.
• Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer's Disease, and Normal Aging.
  Cagnin A, Fragiacomo F, Camporese G, Turco M, Bussè C, Ermani M, Montagnese S. Cagnin A, et al. J Alzheimers Dis. 2017;55(4):1529-1536. doi: 10.3233/JAD-160385. J Alzheimers Dis. 2017. PMID: 27886007
• Sleep disturbances in patients with mild-stage Alzheimer's disease.
  Vitiello MV, Prinz PN, Williams DE, Frommlet MS, Ries RK. Vitiello MV, et al. J Gerontol. 1990 Jul;45(4):M131-8. doi: 10.1093/geronj/45.4.m131. J Gerontol. 1990. PMID: 2365965
• Alzheimer's disease. Sleep and sleep/wake patterns.
  Vitiello MV, Prinz PN. Vitiello MV, et al. Clin Geriatr Med. 1989 May;5(2):289-99. Clin Geriatr Med. 1989. PMID: 2665912 Review.

Cited by

• Abnormalities of Rest-Activity and Light Exposure Rhythms Associated with Cognitive Function in Patients with Mild Cognitive Impairment (MCI).
  Kim SJ, Lee JH, Jang JW, Jung HS, Suh IB. Kim SJ, et al. J Circadian Rhythms. 2023 Dec 28;21:4. doi: 10.5334/jcr.227. eCollection 2023. J Circadian Rhythms. 2023. PMID: 38162255 Free PMC article.
• Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum.
  Ferini-Strambi L, Liguori C, Lucey BP, Mander BA, Spira AP, Videnovic A, Baumann C, Franco O, Fernandes M, Gnarra O, Krack P, Manconi M, Noain D, Saxena S, Kallweit U, Randerath W, Trenkwalder C, Rosenzweig I, Iranzo A, Bradicich M, Bassetti C. Ferini-Strambi L, et al. Neurol Sci. 2024 Feb;45(2):749-767. doi: 10.1007/s10072-023-07232-7. Epub 2023 Dec 13. Neurol Sci. 2024. PMID: 38087143
• Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases.
  Shin JW. Shin JW. Encephalitis. 2023 Apr;3(2):44-53. doi: 10.47936/encephalitis.2022.00094. Epub 2023 Feb 8. Encephalitis. 2023. PMID: 37469673 Free PMC article. Review.
• Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice.
  Soula M, Martín-Ávila A, Zhang Y, Dhingra A, Nitzan N, Sadowski MJ, Gan WB, Buzsáki G. Soula M, et al. Nat Neurosci. 2023 Apr;26(4):570-578. doi: 10.1038/s41593-023-01270-2. Epub 2023 Mar 6. Nat Neurosci. 2023. PMID: 36879142 Free PMC article.
• Sex, Age, and Regional Differences in CHRM1 and CHRM3 Genes Expression Levels in the Human Brain Biopsies: Potential Targets for Alzheimer's Disease-related Sleep Disturbances.
  Sanfilippo C, Giuliano L, Castrogiovanni P, Imbesi R, Ulivieri M, Fazio F, Blennow K, Zetterberg H, Di Rosa M. Sanfilippo C, et al. Curr Neuropharmacol. 2023;21(3):740-760. doi: 10.2174/1570159X21666221207091209. Curr Neuropharmacol. 2023. PMID: 36475335 Free PMC article.

LinkOut - more resources

• Full Text Sources

  • Wiley