Alpha/beta hydrolase fold enzymes: the family keeps growing - PubMed (original) (raw)
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Alpha/beta hydrolase fold enzymes: the family keeps growing
M Nardini et al. Curr Opin Struct Biol. 1999 Dec.
Abstract
The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.
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