Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease - PubMed (original) (raw)
Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease
G Tórsdóttir et al. Pharmacol Toxicol. 1999 Nov.
Abstract
In a previous study we found copper dyshomeostasis in patients with Alzheimer's disease. In this study, levels of copper in plasma, of ceruloplasmin in serum and ceruloplasmin oxidative activity as well as superoxide dismutase (SOD) activity in erythrocytes were determined in 40 patients with Parkinson's disease and their healthy age- and gender-matched controls. Copper concentrations did not differ significantly in the two groups, whereas both ceruloplasmin concentrations and ceruloplasmin oxidative activity were significantly lower in the patients, also relative to ceruloplasmin mass. SOD activity was not significantly different in the two groups but decreased significantly with the duration of disease. The same was found for ceruloplasmin oxidative activity. Ceruloplasmin oxidative activity and SOD activity did not decrease with age. Levels of serum iron, serum ferritin and total iron binding capacity were determined in about 30 of the patients and an equal number of controls and were not found to differ. Transferrin levels were significantly lower in the patients than in their controls but, conversely, the transferrin saturation was significantly higher in the patients. The results indicate that patients with Alzheimer's disease and Parkinson's disease have defective ceruloplasmin and SOD activities in common and that these defects are not necessarily associated with major disturbances in iron homeostasis.
Similar articles
- Copper, ceruloplasmin and superoxide dismutase (SOD) in amyotrophic lateral sclerosis.
Tórsdóttir G, Kristinsson J, Gudmundsson G, Snaedal J, Jóhannesson T. Tórsdóttir G, et al. Pharmacol Toxicol. 2000 Sep;87(3):126-30. doi: 10.1111/j.0901-9928.2000.870305.x. Pharmacol Toxicol. 2000. PMID: 11068853 - Non-anemic iron depletion, oral iron supplementation and indices of copper status in college-aged females.
Gropper SS, Bader-Crowe DM, McAnulty LS, White BD, Keith RE. Gropper SS, et al. J Am Coll Nutr. 2002 Dec;21(6):545-52. doi: 10.1080/07315724.2002.10719253. J Am Coll Nutr. 2002. PMID: 12480800 - Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome.
Tórsdóttir G, Kristinsson J, Hreidarsson S, Snaedal J, Jóhannesson T. Tórsdóttir G, et al. Pharmacol Toxicol. 2001 Dec;89(6):320-5. doi: 10.1034/j.1600-0773.2001.d01-168.x. Pharmacol Toxicol. 2001. PMID: 11903959 Clinical Trial. - [Ceruloplasmin (Cp) and iron in connection with Parkinson's disease (PD) and Alzheimer's disease (AD)].
Johannesson T, Kristinsson J, Torsdottir G, Snaedal J. Johannesson T, et al. Laeknabladid. 2012 Oct;98(10):531-7. doi: 10.17992/lbl.2012.10.457. Laeknabladid. 2012. PMID: 23043066 Review. Icelandic. - Case-control studies on ceruloplasmin and superoxide dismutase (SOD1) in neurodegenerative diseases: a short review.
Torsdottir G, Kristinsson J, Snaedal J, Sveinbjörnsdóttir S, Gudmundsson G, Hreidarsson S, Jóhannesson T. Torsdottir G, et al. J Neurol Sci. 2010 Dec 15;299(1-2):51-4. doi: 10.1016/j.jns.2010.08.047. Epub 2010 Sep 18. J Neurol Sci. 2010. PMID: 20851426 Review.
Cited by
- Role of NAD(+), Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders.
Essa MM, Subash S, Braidy N, Al-Adawi S, Lim CK, Manivasagam T, Guillemin GJ. Essa MM, et al. Int J Tryptophan Res. 2013 Jul 21;6(Suppl 1):15-28. doi: 10.4137/IJTR.S11355. Print 2013. Int J Tryptophan Res. 2013. PMID: 23922500 Free PMC article. - Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration.
Ayton S, Lei P. Ayton S, et al. Biomed Res Int. 2014;2014:581256. doi: 10.1155/2014/581256. Epub 2014 Jan 16. Biomed Res Int. 2014. PMID: 24527451 Free PMC article. Review. - Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy.
Lachowicz JI, Lecca LI, Meloni F, Campagna M. Lachowicz JI, et al. Molecules. 2021 Nov 2;26(21):6639. doi: 10.3390/molecules26216639. Molecules. 2021. PMID: 34771058 Free PMC article. Review. - Copper and copper proteins in Parkinson's disease.
Montes S, Rivera-Mancia S, Diaz-Ruiz A, Tristan-Lopez L, Rios C. Montes S, et al. Oxid Med Cell Longev. 2014;2014:147251. doi: 10.1155/2014/147251. Epub 2014 Jan 8. Oxid Med Cell Longev. 2014. PMID: 24672633 Free PMC article. Review. - Correlations between abnormal iron metabolism and non-motor symptoms in Parkinson's disease.
Xu W, Zhi Y, Yuan Y, Zhang B, Shen Y, Zhang H, Zhang K, Xu Y. Xu W, et al. J Neural Transm (Vienna). 2018 Jul;125(7):1027-1032. doi: 10.1007/s00702-018-1889-x. Epub 2018 May 10. J Neural Transm (Vienna). 2018. PMID: 29748849
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical